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Ultra-deep 3D genome structure mapping with Region Capture Micro-C

ABSTRACT: In an effort to map the deeply map the structure of the genome at loci of interest, we applied Region Capture Micro-C and revealed focal patterns of contact between enhancers & promoters that we term microcompartments. We have mapped genomic structure at 0.4-1.9 Mb-sized regions at the Klf1, Ppm1g, Fbn2, Sox2, and Nanog loci across 4 conditions: wild-type and transcriptionally inhibited mouse Embryonic Stem Cells (mESCs), and cohesin-depletion & control treatments in a RAD21-AID genome-edited mESC line.

ORGANISM(S): Mus musculus Homo sapiens

PROVIDER: GSE207225 | GEO | 2022/07/12

REPOSITORIES: GEO

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