Genomics

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Integrated multi-omics approach revealed cellular senescence landscape


ABSTRACT: Cellular senescence is a complex multifactorial biological phenomenon that plays essential roles in aging, and aging-related diseases. During this process, the senescent cells undergo gene expression altering and chromatin structure remodeling. However, studies on the epigenetic landscape of senescence using integrated multi-omics approaches are limited. In this research, we performed ATAC-seq, RNA-seq, and ChIP-seq on different senescent types to reveal the landscape of senescence and identify the prime regulatory elements.

ORGANISM(S): Homo sapiens

PROVIDER: GSE210285 | GEO | 2022/08/15

REPOSITORIES: GEO

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