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A twin UGUA motif directs the balance between gene isoforms through CFIm and the mTORC1 signaling pathway

ABSTRACT: To identify APA changes in Tsc1-cKO mice, cTag-PAPERCLIP was performed on pAAV-Camk2a-iCre injected Tsc1-WT and Tsc1-floxed cTag-PABP mice. To identify CPSF6-dependent PAS, PAPERCLIP was performed on shCPSF6-BE2C cells with/without doxycycline treatment.

ORGANISM(S): Mus musculus Homo sapiens

PROVIDER: GSE210768 | GEO | 2022/08/11

REPOSITORIES: GEO

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cTag-PAPERCLIP Reveals Alternative Polyadenylation Promotes Cell-Type Specific Protein Diversity and Shifts Araf Isoforms with Microglia Activation

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