CD45+ and CD45- cells of benign v/s metastatic mouse breast tumors

ABSTRACT: Metastasis remains a leading cause of all cancer related mortalities and therapeutic challenges. To successfully establish tumors and metastasiz, cancer cells must escape recognition and elimination by modulating immune cells during surveillance. Therapies that mount anti-tumor response of the adaptive immune system and target the immune evasion mechanisms have entered the clinic. However, the number of patients that respond to these therapies remains humble. This is likely due to the pro-tumor and immunosuppressive mechanisms of innate immune system that remain elusive. Tumor immune cells demonstrate tremendous intra- and inter-tumoral heterogeneity. Presence of high neutrophil to lymphocyte ratio is typically associated with high risk of metastasis and poor patient outcome, which suggests that immune cells, specifically myeloid cells of metastatic tumors have distinct biological functions. We aim to identify these distinct biological functions and the candidates that may have prognostic and therapeutic potential using a non-metastatic and metastatic tumor from the 4T1 mouse breast cancer model.

ORGANISM(S): Mus musculus

PROVIDER: GSE211223 | GEO | 2023/11/22

REPOSITORIES: GEO