Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Defining key transcriptional regulators of extravillous trophoblast differentiation

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Homo sapiens

PROVIDER: GSE212267 | GEO | 2024/01/16

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Defining key transcriptional regulators of extravillous trophoblast differentiation [RNA-seq]

Project description:During early human pregnancy, extravillous trophoblasts (EVT) play a central role in placental anchorage and blood vessel remodeling. Despite the essential roles in pregnancy, key factors and mechanisms underlying EVT differentiation remain largely unknown. Here, we defined key transcription factors (TFs) by monitoring the dynamics of transcriptome and enhancer usage during EVT differentiation. We confirmed the requirements of the defined TFs and identified their action mechanisms.

2024-01-16 | GSE212266 | GEO

Defining key transcriptional regulators of extravillous trophoblast differentiation [ChIP-seq]

2024-01-16 | GSE212265 | GEO

Defining key transcriptional regulators of extravillous trophoblast differentiation

Project description:Defining key transcriptional regulators of extravillous trophoblast differentiation

| PRJNA874727 | ENA

Defining key transcriptional regulators of extravillous trophoblast differentiation [RNA-seq]

Project description:Defining key transcriptional regulators of extravillous trophoblast differentiation [RNA-seq]

| PRJNA874733 | ENA

Defining key transcriptional regulators of extravillous trophoblast differentiation [ChIP-seq]

Project description:Defining key transcriptional regulators of extravillous trophoblast differentiation [ChIP-seq]

| PRJNA874728 | ENA

Transcriptomic Drivers of Differentiation, Maturation, and Polyploidy in Human Extravillous Trophoblast

Project description:This SuperSeries is composed of the SubSeries listed below.

2021-08-10 | GSE173372 | GEO

Epithelial-mesenchymal transition during extravillous trophoblast differentiation.

Project description:A successful pregnancy depends on the intricate and timely interactions of maternal and fetal cells. Placental extravillous cytotrophoblast invasion involves a cellular transition from an epithelial to mesenchymal phenotype. Villous cytotrophoblasts undergo a partial epithelial to mesenchymal transition (EMT) when differentiating into extravillous cytotrophoblasts and gain the capacity to migrate and invade. This review summarizes our current knowledge regarding known regulators of EMT in the human placenta, including the inducers of EMT, upstream transcription factors that control EMT and the downstream effectors, cell adhesion molecules and their differential expression and functions in pregnancy pathologies, preeclampsia (PE) and fetal growth restriction (FGR). The review also describes the research strategies that were used for the identification of the functional role of EMT targets in vitro. A better understanding of molecular pathways driven by placental EMT and further elucidation of signaling pathways underlying the developmental programs may offer novel strategies of targeted therapy for improving feto-placental growth in placental pathologies including PE and FGR.

| S-EPMC4951171 | biostudies-other

Defining the regulons of Pseudomonas aeruginosa transcriptional regulators

Project description:This SuperSeries is composed of the SubSeries listed below.

2021-04-12 | GSE163235 | GEO

NOTUM-MEDIATED WNT SILENCING DRIVES EXTRAVILLOUS TROPHOBLAST CELL LINEAGE DEVELOPMENT

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-03-06 | GSE206036 | GEO

Single Cell Sequencing Identifies Key Epigenetic Regulators in Nuclear Transfer Mediated Reprogramming.

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2016-05-16 | E-GEOD-70608 | biostudies-arrayexpress