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Maternal influences on the transmission of leukocyte gene expression profiles in population samples

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Homo sapiens

PROVIDER: GSE21345 | GEO | 2011/01/01

SECONDARY ACCESSION(S): PRJNA126143

REPOSITORIES: GEO

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Maternal influences on the transmission of leukocyte gene expression profiles in population samples

Project description:This SuperSeries is composed of the following subset Series: GSE21311: Maternal influences on the transmission of leukocyte gene expression profiles in population samples (Red Cross Donors) GSE21342: Maternal influences on the transmission of leukocyte gene expression profiles in population samples (mother and child) Refer to individual Series

2011-01-01 | E-GEOD-21345 | biostudies-arrayexpress

Maternal influences on the transmission of leukocyte gene expression profiles in population samples from Brisbane, Australia.

Project description:Two gene expression profiling studies designed to identify maternal influences on development of the neonate immune system and to address the population structure of the leukocyte transcriptome were carried out in Brisbane, Australia. In the first study, a comparison of 19 leukocyte samples obtained from mothers in the last three weeks of pregnancy with 37 umbilical cord blood samples documented differential expression of 7,382 probes at a false discovery rate of 1%, representing approximately half of the expressed transcriptome. An even larger component of the variation involving 8,432 probes, notably enriched for Vitamin E and methotrexate-responsive genes, distinguished two sets of individuals, with perfect transmission of the two profile types between each of 16 mother-child pairs in the study. A minor profile of variation was found to distinguish the gene expression profiles of obese mothers and children of gestational diabetic mothers from those of children born to obese mothers. The second study was of adult leukocyte profiles from a cross-section of Red Cross blood donors sampled throughout Brisbane. The first two axes in this study are related to the third and fourth axes of variation in the first study and also reflect variation in the abundance of CD4 and CD8 transcripts. One of the profiles associated with the third axis is largely excluded from samples from the central portion of the city. Despite enrichment of insulin signaling and aspects of central metabolism among the differentially expressed genes, there was little correlation between leukocyte expression profiles and body mass index overall. Our data is consistent with the notion that maternal health and cytokine milieu directly impact gene expression in fetal tissues, but that there is likely to be a complex interplay between cultural, genetic, and other environmental factors in the programming of gene expression in leukocytes of newborn children.

| S-EPMC3013110 | biostudies-literature

Maternal influences on the transmission of leukocyte gene expression profiles in population samples (mother and child)

2011-01-01 | GSE21342 | GEO

Maternal influences on the transmission of leukocyte gene expression profiles in population samples (Red Cross Donors)

2011-01-01 | GSE21311 | GEO

Maternal influences on the transmission of leukocyte gene expression profiles in population samples (mother and child)

Project description:This study contrasts the expression profiles of peripheral blood leukocytes from third trimester pregnant mothers, with cord blood leukocytes from their newborn children. It is a companion to (GSE21311). After normalization for RNA integrity, major principal components of the variation were found to distinguish individuals. Transmission of gene expression profiles from mother to child was documented, along with differences between gestational diabetic, obese, and normal weight mothers and their children. 56 individulas (Brisbane, Australia) were sampled for the mother-newborn study, under informed consent. 19 mothers sample were collected in the last month of pregnancy (between 30th and 36th week of pregnancy) and 37 cord blood samples were obtained at birth from newborn babies. Mothers having BMI values over 30 before pregnancy were classified as obese. From the 37 newborn babies, 10 were born to obese mothers, 8 to gestational diabetic mothers (with a wide range of body mass indices), and 19 to normal-weight mothers. There were 16 mother-newborn pairs in the dataset. RNA from each was hybridized to an Illumina HT12 array.

2011-01-01 | E-GEOD-21342 | biostudies-arrayexpress

Maternal influences on the transmission of leukocyte gene expression profiles in population samples (Red Cross Donors)

Project description:This is a companion study to (GSE21342). Peripheral blood leukocyte samples were obtained with consent from 100 red cross blood donors sampled cross-sectionally across the city of Brisbane, Australia. After correction for RNA integrity values, individuals fall into major profiles of expression variation suggesting environmental and cultural influences on immune gene expression. 100 individuals, 50 men and 50 women, were sampled with permission of the Red Cross Society of Australia and under informed consent. The age of individulas were between 18 and 68 (mean 44). BMI ranged from 17.7 to 51.3 with a mean of 26.6. Collection was carried out by EM at mobile Red Cross vans at 10 locations (Bellbowrie, Capalaba, Dayboro, Eagle Farm, Kenmore, Mount Ommaney, South Brisbane, St Lucia, Virginia, and Woolloongabba) distributed across the city.

2011-01-01 | E-GEOD-21311 | biostudies-arrayexpress

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Loss of Linker Histone H1 in the Maternal Genome Influences DEMETER-Mediated Demethylation and Affects the Endosperm DNA Methylation Landscape

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