Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Cell-Type-Specific TGF-beta Signaling is Targeted to Genes that Control Cell Identity: Gene Expression

ABSTRACT: Smad3 co-occupies DNA binding sites with master transcription factors.

ORGANISM(S): Mus musculus

PROVIDER: GSE21608 | GEO | 2011/08/24

SECONDARY ACCESSION(S): PRJNA129303

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Cell-Type-Specific TGF-beta Signaling is Targeted to Genes that Control Cell Identity: ChIP-Seq

Project description:Smad3 co-occupies DNA binding sites with master transcription factors. Pu.1, MyoD, Oct4, IgG, Smad3, and Smad2/3 ChIP-Seq.

2011-08-24 | E-GEOD-21614 | biostudies-arrayexpress

Cell-Type-Specific TGF-beta Signaling is Targeted to Genes that Control Cell Identity: Gene Expression

Project description:Smad3 co-occupies DNA binding sites with master transcription factors. Treated (Cy5) vs. untreated (Cy3).

2011-08-23 | E-GEOD-21608 | biostudies-arrayexpress

Cell-Type-Specific TGF-beta Signaling is Targeted to Genes that Control Cell Identity: ChIP-Seq

Project description:Smad3 co-occupies DNA binding sites with master transcription factors.

2011-08-24 | GSE21614 | GEO

Cell-Type-Specific TGF-beta Signaling is Targeted to Genes that Control Cell Identity

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2011-08-24 | E-GEOD-21621 | biostudies-arrayexpress

Cell-Type-Specific TGF-beta Signaling is Targeted to Genes that Control Cell Identity

Project description:This SuperSeries is composed of the SubSeries listed below.

2011-08-24 | GSE21621 | GEO

Protection from obesity and diabetes by blockade of TGF-beta/Smad3 signaling

Project description:Imbalances in glucose and energy homeostasis are at the core of the worldwide epidemic of obesity and diabetes. Here, we illustrate an important role of the TGF-beta/Smad3 signaling pathway in regulating glucose and energy homeostasis. Smad3 deficient mice are protected from diet-induced obesity and diabetes. Interestingly, the metabolic protection is accompanied by Smad3-/- white adipose tissue acquiring the bioenergetic and gene expression profile of brown fat/skeletal muscle. Smad3-/- adipocytes demonstrate a marked increase in mitochondrial biogenesis, with a corresponding increase in basal respiration, and Smad3 acts as a repressor of PGC-alpha1 expression. We observe significant correlation between TGF-beta1 levels and adiposity in rodents and humans. Further, systemic blockade of TGF-beta1 signaling protects mice from obesity, diabetes and hepatic steatosis. Together, these results demonstrate that TGF-beta signaling regulates glucose tolerance and energy homeostasis and suggest that modulation of TGF-beta1 activity might be an effective treatment strategy for obesity and diabetes. Smad3-/- and WT mice were fed with regular diet (RD) and high fat diet (HFD), and diet induced obese (DIO) mice were treated with IgG and anti-TGF-b1 antibody

2011-07-12 | E-GEOD-28598 | biostudies-arrayexpress

Cell-Type-Specific TGF-beta Signaling is Targeted to Genes that Control Cell Identity

Project description:Cell-Type-Specific TGF-beta Signaling is Targeted to Genes that Control Cell Identity

| PRJNA127109 | ENA

Protection from obesity and diabetes by blockade of TGF-beta/Smad3 signaling

2011-07-13 | GSE28598 | GEO

A general transcription co-factor, Smad3, potentiates master transcription factor mediated cell identity conversions [ChIP-seq]

Project description:We have identified that expression of constitutive active Smad3 (Smad3CA) significantly enhanced reprogramming by Oct4, Sox2, Klf4, c-Myc. Smad3 is known to interact with several master transcription factors and boost their activity during development. Therefore, we hypothesized that Smad3CA is recruited to Oct4 binding sites during reprogramming. To test this hypothesis, we investigated genome-wide Smad3 binding sites in the presence and absence of reprogramming factor expression.

2017-11-03 | GSE85177 | GEO

Cell-Type-Specific TGF-beta Signaling is Targeted to Genes that Control Cell Identity: ChIP-Seq

Project description:Cell-Type-Specific TGF-beta Signaling is Targeted to Genes that Control Cell Identity: ChIP-Seq

| PRJNA129305 | ENA