Transcriptomics

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Transcriptome changes in a rat model of progressive heart failure


ABSTRACT: Heart failure is among the leading causes of death globally. Ventricular failure progresses through a hypertrophic compensatory phase followed by failure of the ventricle function through rapid decompensation. In order to unravel right heart specific mechanisms of disease, rat animal models were established that (i) reflect the slowly progressive mode of compensation / decompensation and (ii) allow comparative analyses of left versus right heart failure in the same experimental set up. Differential gene expression analysis was performed for all three treatment groups (sham, AOB, PAB), at both time points (compensation, decompensation) and for both ventricles as well as the septum

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE216264 | GEO | 2024/04/15

REPOSITORIES: GEO

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