Transcriptomics

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Gene expression data of interleukin-7-dependent and BCR-ABL1-transformed pre-B cells


ABSTRACT: This analysis focused on identifying factors that protect pre-B cells against DNA double strand break (DSB)-mediated DNA damage stress during pre-B cell differentiation. Differentiation of pre-B cells including immunoglobulin light chain gene recombination were performed by withdrawal of interleukin-7 (IL-7) from IL-7-dependent murine pre-B cells or by inhibition of the BCR-ABL1 kinase activity in BCR-ABL1-transformed pre-B cells. The BCR-ABL1 kinase inhibitor STI571 (Imatinib) was used for the inhibition of BCR-ABL1.

ORGANISM(S): Mus musculus

PROVIDER: GSE21664 | GEO | 2010/05/10

SECONDARY ACCESSION(S): PRJNA125901

REPOSITORIES: GEO

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