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The Groucho/Tle coregulators are essential for early thymic progenitors and T-cell lineage specification [ATAC-seq]

ABSTRACT: The goal of this study is to determine the functional requirements for Groucho/Tle coregulators in early stages of T cell development. By ablating three mammalian homologues, Tle1, Tle3, and Tle4 genes, we found that Tle1/3/4 are essential for repressing non-T cell lineage potential in early thymic progenitors, and therefore pivotal for T-cell lineage specification.

ORGANISM(S): Mus musculus

PROVIDER: GSE217023 | GEO | 2022/11/06

REPOSITORIES: GEO

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The Groucho/Tle coregulators are essential for early thymic progenitors and T-cell lineage specification [Cut&Run]

Project description:The goal of this study is to determine the functional requirements for Groucho/Tle coregulators in early stages of T cell development. By ablating three mammalian homologues, Tle1, Tle3, and Tle4 genes, we found that Tle1/3/4 are essential for repressing non-T cell lineage potential in early thymic progenitors, and therefore pivotal for T-cell lineage specification.

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