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The Groucho/Tle coregulators are essential for early thymic progenitors and T-cell lineage specification [Cut&Run]

ABSTRACT: The Groucho/Tle coregulators are essential for early thymic progenitors and T-cell lineage specification [Cut&Run]

PROVIDER: PRJNA896589 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR22130866_1.fastq.gz	Fastqsanger.gz
	SRR22130866_2.fastq.gz	Fastqsanger.gz
	SRR22130867_1.fastq.gz	Fastqsanger.gz
	SRR22130867_2.fastq.gz	Fastqsanger.gz
	SRR22130868_1.fastq.gz	Fastqsanger.gz

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The Groucho/Tle coregulators are essential for early thymic progenitors and T-cell lineage specification [RNA-seq]

Project description:The goal of this study is to determine the functional requirements for Groucho/Tle coregulators in early stages of T cell development. By ablating three mammalian homologues, Tle1, Tle3, and Tle4 genes, we found that Tle1/3/4 are essential for repressing non-T cell lineage potential in early thymic progenitors, and therefore pivotal for T-cell lineage specification.

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The Groucho/Tle coregulators are essential for early thymic progenitors and T-cell lineage specification [Cut&Run]

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The Groucho/Tle coregulators are essential for early thymic progenitors and T-cell lineage specification

Project description:The Groucho/Tle coregulators are essential for early thymic progenitors and T-cell lineage specification

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The Groucho/Tle coregulators are essential for early thymic progenitors and T-cell lineage specification [ATAC-seq]

Project description:The Groucho/Tle coregulators are essential for early thymic progenitors and T-cell lineage specification [ATAC-seq]

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The Groucho/Tle coregulators are essential for early thymic progenitors and T-cell lineage specification [RNA-seq]

Project description:The Groucho/Tle coregulators are essential for early thymic progenitors and T-cell lineage specification [RNA-seq]

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The Groucho/Tle coregulators are essential for early thymic progenitors and T-cell lineage specification

Project description:This SuperSeries is composed of the SubSeries listed below.

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Occupancies of tissue-specific cis-regulatory modules by Spemann-Mangold organizer-specific transcription factors for embryonic head specification

Project description:Spemann-Mangold organizer-specific transcription factors (TFs), Otx2, Lim1/Lhx1, and Gsc, are essential for embryonic head specification. However, the molecular mechanisms by which those TFs interact with the genome to direct head formation are largely unknown. Here we employed ChIP-seq and RNA-seq approaches in Xenopus tropicalis gastrulae and found that occupancy of the corepressor, TLE/Groucho, is a better indicator of tissue-specific cis-regulatory modules (CRMs) than the coactivator p300, during early embryonic stages. On the basis of TLE binding and comprehensive CRM profiling, we defined two distinct types of Otx2- and TLE-occupied CRMs. Using these devices, Otx2 and Lim1/Lhx1 (activator) or Goosecoid (repressor) are able to upregulate or downregulate a large battery of target genes in the head organizer. An underlying principle is that Otx marks target genes for head specification to be regulated positively or negatively by partner TFs through specific types of CRMs.

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Occupancy of tissue-specific cis-regulatory modules by Otx2 and TLE/Groucho for embryonic head specification.

Project description:Head specification by the head-selector gene, orthodenticle (otx), is highly conserved among bilaterian lineages. However, the molecular mechanisms by which Otx and other transcription factors (TFs) interact with the genome to direct head formation are largely unknown. Here we employ ChIP-seq and RNA-seq approaches in Xenopus tropicalis gastrulae and find that occupancy of the corepressor, TLE/Groucho, is a better indicator of tissue-specific cis-regulatory modules (CRMs) than the coactivator p300, during early embryonic stages. On the basis of TLE binding and comprehensive CRM profiling, we define two distinct types of Otx2- and TLE-occupied CRMs. Using these devices, Otx2 and other head organizer TFs (for example, Lim1/Lhx1 (activator) or Goosecoid (repressor)) are able to upregulate or downregulate a large battery of target genes in the head organizer. An underlying principle is that Otx marks target genes for head specification to be regulated positively or negatively by partner TFs through specific types of CRMs.

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