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Gene expression in Lineage negative bone marrow cells of C57B/L6 and B.D(Chr5) mice

ABSTRACT: These mouse strains differ in absolute numbers of hematopoietic stem cells but differ genetically only at the Chr 5 congenic locus. We used microarray analysis to identify candidate regulators of hematopoietic stem cells based on differential gene expression patterns.

ORGANISM(S): Mus musculus

PROVIDER: GSE21905 | GEO | 2010/05/21

SECONDARY ACCESSION(S): PRJNA126825

REPOSITORIES: GEO

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Gene expression in Lineage negative bone marrow cells of C57B/L6 and B.D(Chr5) mice

Project description:These mouse strains differ in absolute numbers of hematopoietic stem cells but differ genetically only at the Chr 5 congenic locus. We used microarray analysis to identify candidate regulators of hematopoietic stem cells based on differential gene expression patterns. Triplicate RNA samples were isolated from 500,00-800,000 Lineage negative bone marrow cells from each strain. Each of the six samples were analyzed on 6 separate MG 430 2.0 Affymetrix Microarray Chips.

2010-06-08 | E-GEOD-21905 | biostudies-arrayexpress

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Gene expression in LSK cells of C57B/L6, DBA/2J, B.D(Chr5), & D.B(Chr5) mice

Project description:These mouse strains differ in absolute numbers of hematopoietic stem cells but differ genetically only at the Chr 5 congenic locus. We used microarray analysis to identify candidate regulators of hematopoietic stem cells based on differential gene expression patterns. Triplicate RNA samples, except for duplicate DBA/2J samples, were isolated from 80,00-137,000 LSK cells from each strain. Each of the 11 samples were analyzed on individual microarrays on two Illumina Sentrix-Mouse 6 Whole Genome Expression Beadhips.

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