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Super-enhancer-driven MLX mediates redox balance maintanance via SLC7A11 in osteosarcoma

ABSTRACT: A systematic analysis of super-enhancers identified MLX as a potential oncogene in osteosarcoma. Knockdown of MLX impaired tumor aggressiveness in vitro and in vivo, suggesting oncogenic properties of MLX. Mechanistically, silencing of MLX downregulates SLC7A11, a key gene encoding glutamate/cystine antiporter, to attenuate the uptake of cystine and interrupt the redox balance, leading to ferroptotic cell death. Pharmacological inhibition of SLC7A11 triggered massive ferroptosis and caused impaired tumor growth, providing a promising approach for osteosarcoma treatment.

ORGANISM(S): Homo sapiens

PROVIDER: GSE220173 | GEO | 2023/08/08

REPOSITORIES: GEO

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Super-enhancer-driven MLX mediates redox balance maintanance via SLC7A11 in osteosarcoma

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