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PBRM1 bromodomains associate with RNA to facilitate chromatin association

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Homo sapiens

PROVIDER: GSE221620 | GEO | 2023/02/24

REPOSITORIES: GEO

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PBRM1 bromodomains associate with RNA to facilitate chromatin association.

Project description:PBRM1 is a subunit of the PBAF chromatin remodeling complex, which is mutated in 40-50% of clear cell renal cell carcinoma patients. It is thought to largely function as a chromatin binding subunit of the PBAF complex, but the molecular mechanism underlying this activity is not fully known. PBRM1 contains six tandem bromodomains which are known to cooperate in binding of nucleosomes acetylated at histone H3 lysine 14 (H3K14ac). Here, we demonstrate that the second and fourth bromodomains from PBRM1 also bind nucleic acids, selectively associating with double stranded RNA elements. Disruption of the RNA binding pocket is found to compromise PBRM1 chromatin binding and inhibit PBRM1-mediated cellular growth effects.

| S-EPMC10164552 | biostudies-literature

PBRM1 bromodomains associate with RNA to facilitate chromatin association (CLIP-seq)

Project description:PBRM1 is a subunit of the PBAF chromatin remodeling complex, which is mutated in 40-50% of clear cell renal cell carcinoma patients. It is thought to largely function as a chromatin binding subunit of the PBAF complex, but the molecular mechanism underlying this activity is not fully known. PBRM1 contains six tandem bromodomains which are known to cooperate in binding of nucleosomes acetylated at histone H3 lysine 14 (H3K14ac). Using H3K14Ac and PHF10 ChIP-seq, along with CLIP-seq in Caki2 renal cancer cells, we demonstrate here that the second and fourth bromodomains from PBRM1 also bind nucleic acids, selectively associating with double stranded RNA elements. Disruption of the RNA binding pocket is found to compromise PBRM1 chromatin binding and inhibit PBRM1-mediated cellular growth effects.

2023-02-24 | GSE221619 | GEO

PBRM1 bromodomains associate with RNA to facilitate chromatin association (ChIP-seq)

Project description:PBRM1 is a subunit of the PBAF chromatin remodeling complex, which is mutated in 40-50% of clear cell renal cell carcinoma patients. It is thought to largely function as a chromatin binding subunit of the PBAF complex, but the molecular mechanism underlying this activity is not fully known. PBRM1 contains six tandem bromodomains which are known to cooperate in binding of nucleosomes acetylated at histone H3 lysine 14 (H3K14ac). Using H3K14Ac and PHF10 ChIP-seq, along with CLIP-seq in Caki2 renal cancer cells, we demonstrate here that the second and fourth bromodomains from PBRM1 also bind nucleic acids, selectively associating with double stranded RNA elements. Disruption of the RNA binding pocket is found to compromise PBRM1 chromatin binding and inhibit PBRM1-mediated cellular growth effects.

2023-02-24 | GSE221618 | GEO

PBRM1 bromodomains associate with RNA to facilitate chromatin association

Project description:PBRM1 bromodomains associate with RNA to facilitate chromatin association

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PBRM1 bromodomains associate with RNA to facilitate chromatin association (CLIP-seq)

Project description:PBRM1 bromodomains associate with RNA to facilitate chromatin association (CLIP-seq)

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PBRM1 bromodomains associate with RNA to facilitate chromatin association (ChIP-seq)

Project description:PBRM1 bromodomains associate with RNA to facilitate chromatin association (ChIP-seq)

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