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Mast cell tolerance in the skin microenvironment to commensal bacteria is controlled by fibroblasts

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Homo sapiens

PROVIDER: GSE223180 | GEO | 2023/05/02

REPOSITORIES: GEO

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Mast cell tolerance in the skin microenvironment to commensal bacteria is controlled by fibroblasts [triplicates]

Project description:To investigate the cooperative function of dermal fibroblast and mast cell in inducing mast cell tolerance to commensals We then performed gene expression profiling analysis using data obtained from RNA-seq of mast cells, and mast cells conditioned by dermal fibroblasts before and after treatments with commensal bacteria supernatants.

2023-05-02 | GSE223179 | GEO

Mast cell tolerance in the skin microenvironment to commensal bacteria is controlled by fibroblasts [LTA]

2023-05-02 | GSE223177 | GEO

Mast cell tolerance in the skin microenvironment to commensal bacteria is controlled by fibroblasts [single-cell RNA-seq]

Project description:To investigate the cooperative function of dermal fibroblast and mast cell in inducing mast cell tolerance to commensals We then performed gene expression profiling analysis using data obtained from SC RNA seq of mast cells, dermal fibroblast and and mast cells in co culture with dermal fibroblasts .

2023-05-02 | GSE223178 | GEO

Mast cell tolerance in the skin microenvironment to commensal bacteria is controlled by fibroblasts

Project description:Mast cell tolerance in the skin microenvironment to commensal bacteria is controlled by fibroblasts

| PRJNA925177 | ENA

Mast cell tolerance in the skin microenvironment to commensal bacteria is controlled by fibroblasts [triplicates]

Project description:Mast cell tolerance in the skin microenvironment to commensal bacteria is controlled by fibroblasts [triplicates]

| PRJNA925184 | ENA

Mast cell tolerance in the skin microenvironment to commensal bacteria is controlled by fibroblasts [LTA]

Project description:Mast cell tolerance in the skin microenvironment to commensal bacteria is controlled by fibroblasts [LTA]

| PRJNA925178 | ENA

Mast cell tolerance in the skin microenvironment to commensal bacteria is controlled by fibroblasts [single-cell RNA-seq]

Project description:Mast cell tolerance in the skin microenvironment to commensal bacteria is controlled by fibroblasts [single-cell RNA-seq]

| PRJNA925179 | ENA

Commensal skin bacteria exacerbate inflammation and delay skin healing.

Project description:The skin microbiome can both trigger beneficial immune stimulation and pose a potential infection threat. Previous studies have shown that colonization of mouse skin with the model human skin commensal Staphylococcus epidermidis is protective against subsequent excisional wound or pathogen challenge. However, less is known about concurrent skin damage and exposure to commensal microbes, despite growing interest in interventional probiotic therapy. Here, we address this open question by applying commensal skin bacteria at a high dose to abraded skin. While depletion of the skin microbiome via antibiotics delayed repair from damage, application of commensals-- including the mouse commensal Staphylococcus xylosus, three distinct isolates of S. epidermidis, and all other tested human skin commensals-- also significantly delayed barrier repair. Increased inflammation was observed within four hours of S. epidermidis exposure and persisted through day four, at which point the skin displayed a chronic-wound-like inflammatory state with increased neutrophil infiltration, increased fibroblast activity, and decreased monocyte differentiation. Transcriptomic analysis suggested that the prolonged upregulation of early canonical proliferative pathways inhibited the progression of barrier repair. These results highlight the nuanced role of members of the skin microbiome in modulating barrier integrity and indicate the need for caution in their development as probiotics.

| S-EPMC10723327 | biostudies-literature

Bacteria Induce Skin Regeneration via IL-1 Signaling

Project description:This SuperSeries is composed of the SubSeries listed below.

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Correcting Direct Effects of Ethanol on Translation and Transcription Machinery Confers Ethanol Tolerance in Bacteria

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

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