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Mast cell tolerance in the skin microenvironment to commensal bacteria is controlled by fibroblasts [LTA]

ABSTRACT: Mast cell tolerance in the skin microenvironment to commensal bacteria is controlled by fibroblasts [LTA]

PROVIDER: PRJNA925178 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR23111280.fastq.gz	Fastqsanger.gz
	SRR23111281.fastq.gz	Fastqsanger.gz
	SRR23111282.fastq.gz	Fastqsanger.gz
	SRR23111283.fastq.gz	Fastqsanger.gz
	SRR23111284.fastq.gz	Fastqsanger.gz

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Mast cell tolerance in the skin microenvironment to commensal bacteria is controlled by fibroblasts [LTA]

Project description:To investigate the cooperative function of dermal fibroblast and mast cell in inducing mast cell tolerance to commensals We then performed gene expression profiling analysis using data obtained from RNA-seq of mast cells, and mast cells conditioned by dermal fibroblasts before and after treatments with commensal bacteria supernatants.

2023-05-02 | GSE223177 | GEO

Mast cell tolerance in the skin microenvironment to commensal bacteria is controlled by fibroblasts [triplicates]

2023-05-02 | GSE223179 | GEO

Mast cell tolerance in the skin microenvironment to commensal bacteria is controlled by fibroblasts

Project description:Mast cell tolerance in the skin microenvironment to commensal bacteria is controlled by fibroblasts

| PRJNA925177 | ENA

Mast cell tolerance in the skin microenvironment to commensal bacteria is controlled by fibroblasts [triplicates]

Project description:Mast cell tolerance in the skin microenvironment to commensal bacteria is controlled by fibroblasts [triplicates]

| PRJNA925184 | ENA

Mast cell tolerance in the skin microenvironment to commensal bacteria is controlled by fibroblasts [single-cell RNA-seq]

Project description:To investigate the cooperative function of dermal fibroblast and mast cell in inducing mast cell tolerance to commensals We then performed gene expression profiling analysis using data obtained from SC RNA seq of mast cells, dermal fibroblast and and mast cells in co culture with dermal fibroblasts .

2023-05-02 | GSE223178 | GEO

Mast cell tolerance in the skin microenvironment to commensal bacteria is controlled by fibroblasts [single-cell RNA-seq]

Project description:Mast cell tolerance in the skin microenvironment to commensal bacteria is controlled by fibroblasts [single-cell RNA-seq]

| PRJNA925179 | ENA

Mast cell tolerance in the skin microenvironment to commensal bacteria is controlled by fibroblasts

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-05-02 | GSE223180 | GEO

Synovial microenvironment-influenced mast cells promote the progression of rheumatoid arthritis

Project description:Mast cells are phenotypically and functionally highly heterogeneous, and their state is possibly controlled by their local microenvironment. Therefore, concrete analyses are needed to understand whether mast cells act as powerful motivators or dispensable bystanders in specific diseases. Here, we evaluated the correlation between synovial mast cells and rheumatoid arthritis (RA) disease severity, and the efficacy of therapeutic interventions against mast cells. We showed that degranulation of mast cells in inflammatory synovial tissues of RA patients was induced via MAS-related G protein-coupled receptor X2 (MRGPRX2), and the expression of MHC class II (MHC II) and costimulatory molecules on mast cells were upregulated. These unique signaling response led to mast cell activation and promoted T cell responses, resulting in the progression of RA. Collagen-induced arthritis mouse models treated with a combination of anti-IL-17A and cromolyn sodium, a mast cell membrane stabilizer, showed significantly reduced clinical severity and decreased bone erosion. The findings of the present study suggest that synovial microenvironment-influenced mast cells contribute to RA and may provide a novel mast cell-targeting therapy for RA.

2024-01-07 | PXD038584 | Pride

Human connective tissue mast cell proteome

Project description:Mast cells are hematopoietic cells that reside preferentially in tissues exposed to internal and external environments. Mast cells sense immunological, inflammatory and environmental stimuli, and can be activated to release granules and generate inflammatory mediators. Mast cell-derived products confer protection against snake venoms and some parasite infections. Aberrant activation of mast cells is a major contributor to human pathology, including allergy, asthma and adverse drug reactions. Their strict tissue location has largely impeded the isolation of large numbers of primary mast cell for further analysis. To better understand the biology of mast cells, we analyzed the proteome of primary human and mouse mast cells by quantitative mass spectrometry. We identified a mast cell-specific protein signature that was conserved from mouse to man. Compared to a comprehensive set of other immune cell lineages, proteome analysis identified a unique and distant mast cell cluster. The mast cell signature included proteins governing granule biosynthesis and secretion, as well as proteoglycan- and neurotransmitter metabolism. Proteome conservation across species suggests evolutionary maintenance of mast cell functions.

2020-02-12 | PXD014978 | Pride

Commensal bacteria promote type I interferon signaling to maintain immune tolerance in mice

Project description:Type I interferons (IFNs) exert a broad range of biological effects important in coordinating immune responses, which have classically been studied in the context of pathogen clearance. Yet, whether immunomodulatory bacteria operate through IFN pathways to support intestinal immune tolerance remains elusive. Here, we reveal that the commensal bacterium, Bacteroides fragilis, utilizes canonical antiviral pathways to modulate intestinal dendritic cells (DCs) and regulatory T cell (Treg) responses. Specifically, IFN signaling is required for commensal-induced tolerance, as IFNAR1-deficient DCs display blunted IL-10 and IL-27 production in response to B. fragilis. We further establish that IFN-driven IL-27 in DCs is critical in shaping the ensuing Foxp3+ Treg via IL27Ra signaling. Consistent with these findings, single cell RNA sequencing of gut Tregs demonstrated that colonization with B. fragilis promotes a distinct IFN gene signature in Foxp3+ Tregs during intestinal inflammation. Altogether, our findings demonstrate a critical role of commensal-mediated immune tolerance via tonic type I IFN signaling.

2023-12-05 | GSE248021 | GEO

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