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Mast cell tolerance in the skin microenvironment to commensal bacteria is controlled by fibroblasts

ABSTRACT: Mast cell tolerance in the skin microenvironment to commensal bacteria is controlled by fibroblasts

PROVIDER: PRJNA925177 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR23111219.fastq.gz	Fastqsanger.gz
	SRR23111220.fastq.gz	Fastqsanger.gz
	SRR23111221.fastq.gz	Fastqsanger.gz
	SRR23111222.fastq.gz	Fastqsanger.gz
	SRR23111223.fastq.gz	Fastqsanger.gz

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Mast cell tolerance in the skin microenvironment to commensal bacteria is controlled by fibroblasts [triplicates]

Project description:To investigate the cooperative function of dermal fibroblast and mast cell in inducing mast cell tolerance to commensals We then performed gene expression profiling analysis using data obtained from RNA-seq of mast cells, and mast cells conditioned by dermal fibroblasts before and after treatments with commensal bacteria supernatants.

2023-05-02 | GSE223179 | GEO

Mast cell tolerance in the skin microenvironment to commensal bacteria is controlled by fibroblasts [LTA]

2023-05-02 | GSE223177 | GEO

Mast cell tolerance in the skin microenvironment to commensal bacteria is controlled by fibroblasts [LTA]

Project description:Mast cell tolerance in the skin microenvironment to commensal bacteria is controlled by fibroblasts [LTA]

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Mast cell tolerance in the skin microenvironment to commensal bacteria is controlled by fibroblasts [triplicates]

Project description:Mast cell tolerance in the skin microenvironment to commensal bacteria is controlled by fibroblasts [triplicates]

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Mast cell tolerance in the skin microenvironment to commensal bacteria is controlled by fibroblasts [single-cell RNA-seq]

Project description:Mast cell tolerance in the skin microenvironment to commensal bacteria is controlled by fibroblasts [single-cell RNA-seq]

| PRJNA925179 | ENA

Mast cell tolerance in the skin microenvironment to commensal bacteria is controlled by fibroblasts [single-cell RNA-seq]

Project description:To investigate the cooperative function of dermal fibroblast and mast cell in inducing mast cell tolerance to commensals We then performed gene expression profiling analysis using data obtained from SC RNA seq of mast cells, dermal fibroblast and and mast cells in co culture with dermal fibroblasts .

2023-05-02 | GSE223178 | GEO

Synovial microenvironment-influenced mast cells promote the progression of rheumatoid arthritis

Project description:Mast cells are phenotypically and functionally highly heterogeneous, and their state is possibly controlled by their local microenvironment. Therefore, concrete analyses are needed to understand whether mast cells act as powerful motivators or dispensable bystanders in specific diseases. Here, we evaluated the correlation between synovial mast cells and rheumatoid arthritis (RA) disease severity, and the efficacy of therapeutic interventions against mast cells. We showed that degranulation of mast cells in inflammatory synovial tissues of RA patients was induced via MAS-related G protein-coupled receptor X2 (MRGPRX2), and the expression of MHC class II (MHC II) and costimulatory molecules on mast cells were upregulated. These unique signaling response led to mast cell activation and promoted T cell responses, resulting in the progression of RA. Collagen-induced arthritis mouse models treated with a combination of anti-IL-17A and cromolyn sodium, a mast cell membrane stabilizer, showed significantly reduced clinical severity and decreased bone erosion. The findings of the present study suggest that synovial microenvironment-influenced mast cells contribute to RA and may provide a novel mast cell-targeting therapy for RA.

2024-01-07 | PXD038584 | Pride

Mast cell tolerance in the skin microenvironment to commensal bacteria is controlled by fibroblasts

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-05-02 | GSE223180 | GEO

Commensal bacteria promote type I interferon signaling to maintain immune tolerance in mice

Project description:Type I interferons (IFNs) exert a broad range of biological effects important in coordinating immune responses, which have classically been studied in the context of pathogen clearance. Yet, whether immunomodulatory bacteria operate through IFN pathways to support intestinal immune tolerance remains elusive. Here, we reveal that the commensal bacterium, Bacteroides fragilis, utilizes canonical antiviral pathways to modulate intestinal dendritic cells (DCs) and regulatory T cell (Treg) responses. Specifically, IFN signaling is required for commensal-induced tolerance, as IFNAR1-deficient DCs display blunted IL-10 and IL-27 production in response to B. fragilis. We further establish that IFN-driven IL-27 in DCs is critical in shaping the ensuing Foxp3+ Treg via IL27Ra signaling. Consistent with these findings, single cell RNA sequencing of gut Tregs demonstrated that colonization with B. fragilis promotes a distinct IFN gene signature in Foxp3+ Tregs during intestinal inflammation. Altogether, our findings demonstrate a critical role of commensal-mediated immune tolerance via tonic type I IFN signaling.

2023-12-05 | GSE248021 | GEO

Skin and Skin Draining lymph node dendritic cells from neonatal mouse colonized with a commensal or control

Project description:Early life establishment of tolerance to commensal bacteria at barrier surfaces carries enduring implications for immune health but remains poorly understood. Here we show that this process is controlled by microbial interaction with a specialized subset of antigen presenting cells. More particularly, we identify CD301b+ type 2 conventional dendritic cells (DC) as a subset in neonatal skin specifically capable of uptake, presentation and generation of regulatory T cells (Tregs) to commensal antigens. In early life, CD301b+ DC2 are enriched for programs of phagocytosis and maturation, while also expressing tolerogenic markers. In both human and murine skin, these signatures were reinforced by microbial uptake. In contrast to their adult counterparts or other early life DC subsets, neonatal CD301b+ DC2 highly expressed the retinoic acid-producing enzyme, RALDH2, deletion of which limited commensal-specific Tregs. Thus, synergistic interactions between bacteria and a specialized DC subset critically support early life tolerance at the cutaneous interface.

2023-01-01 | GSE206892 | GEO

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