Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Loss of MC1R signaling implicates TBX3 in pheomelanogenesis and melanoma predisposition

ABSTRACT: 501mel cells engineered to express ectopically doxycyclin inducible TBX3 3xHA-tagged. Cells were seeded and treated with doxcyclin to achive expression comparable to endogeneous TBX3. 15x 15-cm dish worth of cells were collected for each replicate of ChIP-seq experiments.

ORGANISM(S): Homo sapiens

PROVIDER: GSE223256 | GEO | 2023/08/07

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Loss of MC1R signaling implicates TBX3 in pheomelanogenesis and melanoma predisposition [bulkRNA-seq]

Project description:Comparative gene expression profiling analysis of bulk RNA-seq data for control 501mel cells compared to transient knockdown with two different TBX3 siRNAs

2023-10-01 | GSE236917 | GEO

Loss of MC1R signaling implicates TBX3 in pheomelanogenesis and melanoma predisposition

Project description:Loss of MC1R signaling implicates TBX3 in pheomelanogenesis and melanoma predisposition

| PRJNA925484 | ENA

Loss of MC1R signaling implicates TBX3 in pheomelanogenesis and melanoma predisposition

Project description:Loss of MC1R signaling implicates TBX3 in pheomelanogenesis and melanoma predisposition

| PRJNA993278 | ENA

Loss of MC1R signaling implicates TBX3 in pheomelanogenesis and melanoma predisposition

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-10-01 | GSE237004 | GEO

Loss of MC1R signaling implicates TBX3 in pheomelanogenesis and melanoma predisposition [bulkRNA-seq]

Project description:Loss of MC1R signaling implicates TBX3 in pheomelanogenesis and melanoma predisposition [bulkRNA-seq]

| PRJNA993122 | ENA

Loss of MC1R signaling implicates TBX3 in pheomelanogenesis and melanoma predisposition [scRNA-seq]

Project description:Loss of MC1R signaling implicates TBX3 in pheomelanogenesis and melanoma predisposition [scRNA-seq]

| PRJNA993129 | ENA

Loss of MC1R signaling implicates TBX3 in pheomelanogenesis and melanoma predisposition [scRNA-seq]

Project description:We used single-cell RNA-sequencing (scRNA-seq) of melanocytes isolated from two distict red hair color (RHC) mouse models for comparison with and black hair color, functional MC1R signaling, to reveal a Pheomelanin Gene Signature (PGS) of differentially expressed genes in RHC melanocytes.

2023-10-01 | GSE236918 | GEO

A dynamic role of Tbx3 in the pluripotency circuitry

Project description:Pluripotency represents a cell state comprising a fine-tuned pattern of transcription factor activity required for embryonic stem cell (ESC) self-renewal. TBX3 is the earliest expressed member of the T-box transcription factor family and is involved in maintenance and induction of pluripotency. Hence, TBX3 is believed to be a key member of the pluripotency circuitry, with loss of TBX3 coinciding with loss of pluripotency. We report a dynamic expression of TBX3 in vitro and in vivo using genetic reporter tools tracking TBX3 expression in mouse ESCs (mESCs). Low TBX3 levels are associated with reduced pluripotency, resembling the more mature epiblast. Notably, TBX3-low cells maintain the intrinsic capability to switch to a TBX3-high state and vice versa. Additionally, we show TBX3 to be dispensable for induction and maintenance of naive pluripotency as well as for germ cell development. These data highlight novel facets of TBX3 action in mESCs.

2015-12-09 | GSE73862 | GEO

A dynamic role of Tbx3 in the pluripotency circuitry

2015-12-09 | E-GEOD-73862 | biostudies-arrayexpress

TBX3 defines the functional identity of hypothalamic melanocortin neurons

Project description:Purpose: Identify cellular pathways controlled by Tbx3 Methods: RNA sequencing of hypothalamic primary neurons from Tbx3 loxP/loxP mice infected with Ad-Cre or Ad-GFP viruses. Results: Unbiased pathway analysis revealed that Tbx3 deletion in primary neurons significantly affected the expression of genes involved in several pathways responsible for controlling cellular proliferation, differentiation and determination of cellular fate. Conclusions: Tbx3 in primary neurons might be implicated in the development and maintenance of neuronal identity.

2019-01-22 | GSE119883 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data