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Loss of MC1R signaling implicates TBX3 in pheomelanogenesis and melanoma predisposition [bulkRNA-seq]

ABSTRACT: Comparative gene expression profiling analysis of bulk RNA-seq data for control 501mel cells compared to transient knockdown with two different TBX3 siRNAs

ORGANISM(S): Homo sapiens

PROVIDER: GSE236917 | GEO | 2023/10/01

REPOSITORIES: GEO

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Loss of MC1R signaling implicates TBX3 in pheomelanogenesis and melanoma predisposition

Project description:501mel cells engineered to express ectopically doxycyclin inducible TBX3 3xHA-tagged. Cells were seeded and treated with doxcyclin to achive expression comparable to endogeneous TBX3. 15x 15-cm dish worth of cells were collected for each replicate of ChIP-seq experiments.

2023-08-07 | GSE223256 | GEO

Loss of MC1R signaling implicates TBX3 in pheomelanogenesis and melanoma predisposition [bulkRNA-seq]

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Loss of MC1R signaling implicates TBX3 in pheomelanogenesis and melanoma predisposition

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Loss of MC1R signaling implicates TBX3 in pheomelanogenesis and melanoma predisposition

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Loss of MC1R signaling implicates TBX3 in pheomelanogenesis and melanoma predisposition

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Loss of MC1R signaling implicates TBX3 in pheomelanogenesis and melanoma predisposition [scRNA-seq]

Project description:We used single-cell RNA-sequencing (scRNA-seq) of melanocytes isolated from two distict red hair color (RHC) mouse models for comparison with and black hair color, functional MC1R signaling, to reveal a Pheomelanin Gene Signature (PGS) of differentially expressed genes in RHC melanocytes.

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Loss of MC1R signaling implicates TBX3 in pheomelanogenesis and melanoma predisposition [scRNA-seq]

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A dynamic role of Tbx3 in the pluripotency circuitry

Project description:Pluripotency represents a cell state comprising a fine-tuned pattern of transcription factor activity required for embryonic stem cell (ESC) self-renewal. TBX3 is the earliest expressed member of the T-box transcription factor family and is involved in maintenance and induction of pluripotency. Hence, TBX3 is believed to be a key member of the pluripotency circuitry, with loss of TBX3 coinciding with loss of pluripotency. We report a dynamic expression of TBX3 in vitro and in vivo using genetic reporter tools tracking TBX3 expression in mouse ESCs (mESCs). Low TBX3 levels are associated with reduced pluripotency, resembling the more mature epiblast. Notably, TBX3-low cells maintain the intrinsic capability to switch to a TBX3-high state and vice versa. Additionally, we show TBX3 to be dispensable for induction and maintenance of naive pluripotency as well as for germ cell development. These data highlight novel facets of TBX3 action in mESCs.

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