Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Loss of MC1R signaling implicates TBX3 in pheomelanogenesis and melanoma predisposition [bulkRNA-seq]

ABSTRACT: Loss of MC1R signaling implicates TBX3 in pheomelanogenesis and melanoma predisposition [bulkRNA-seq]

PROVIDER: PRJNA993122 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR25213484_1.fastq.gz	Fastqsanger.gz
	SRR25213484_2.fastq.gz	Fastqsanger.gz
	SRR25213485_1.fastq.gz	Fastqsanger.gz
	SRR25213485_2.fastq.gz	Fastqsanger.gz
	SRR25213486_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 18

Similar Datasets

Loss of MC1R signaling implicates TBX3 in pheomelanogenesis and melanoma predisposition

Project description:Loss of MC1R signaling implicates TBX3 in pheomelanogenesis and melanoma predisposition

| PRJNA925484 | ENA

Loss of MC1R signaling implicates TBX3 in pheomelanogenesis and melanoma predisposition

Project description:Loss of MC1R signaling implicates TBX3 in pheomelanogenesis and melanoma predisposition

| PRJNA993278 | ENA

Loss of MC1R signaling implicates TBX3 in pheomelanogenesis and melanoma predisposition [scRNA-seq]

Project description:Loss of MC1R signaling implicates TBX3 in pheomelanogenesis and melanoma predisposition [scRNA-seq]

| PRJNA993129 | ENA

Loss of MC1R signaling implicates TBX3 in pheomelanogenesis and melanoma predisposition [bulkRNA-seq]

Project description:Comparative gene expression profiling analysis of bulk RNA-seq data for control 501mel cells compared to transient knockdown with two different TBX3 siRNAs

2023-10-01 | GSE236917 | GEO

Loss of MC1R signaling implicates TBX3 in pheomelanogenesis and melanoma predisposition

Project description:501mel cells engineered to express ectopically doxycyclin inducible TBX3 3xHA-tagged. Cells were seeded and treated with doxcyclin to achive expression comparable to endogeneous TBX3. 15x 15-cm dish worth of cells were collected for each replicate of ChIP-seq experiments.

2023-08-07 | GSE223256 | GEO

Loss of MC1R signaling implicates TBX3 in pheomelanogenesis and melanoma predisposition [scRNA-seq]

Project description:We used single-cell RNA-sequencing (scRNA-seq) of melanocytes isolated from two distict red hair color (RHC) mouse models for comparison with and black hair color, functional MC1R signaling, to reveal a Pheomelanin Gene Signature (PGS) of differentially expressed genes in RHC melanocytes.

2023-10-01 | GSE236918 | GEO

Loss of MC1R signaling implicates TBX3 in pheomelanogenesis and melanoma predisposition

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-10-01 | GSE237004 | GEO

MC1R stabilize the actin cytoskeleton

Project description:Amplification of the Melanocortin-1 Receptor in Nephrotic Syndrome Renders a Good Target for Podocyte Cytoskeleton Stabilization During the last years, several reports have been presented of beneficial effects of ACTH in patients with nephrotic syndrome. Among the known ACTH receptors, the melanocortin-1 receptor (MC1R) has been suggested as the mediator of the ACTH renoprotective effect with the mechanism of action resulting in stabilization of the actin cytoskeleton in podocytes. To understand how melanocortin receptors are regulated in nephrotic syndrome and how they are involved in restoration of filtration barrier function, melanocortin receptor expression was evaluated in patients and in a rat model of nephrotic syndrome in combination with cell culture analysis. Phosphoproteomic mass spectrometry was applied and identified MC1R pathways confirmed using biochemical analysis. We found that glomerular MC1R expression was increased in nephrotic syndrome, both in humans and in a rat model. A MC1R agonist protected podocytes from protamine sulfate induced stress fiber loss with the top ranked phoshoproteomic MC1R activated pathway beeing actin cytoskeleton signaling. Actin stabilization through the MC1R consisted of ERK1/2 dependent phosphorylation and inactivation of EGFR signaling with stabilization of synaptopodin and stress fibers in podocytes. These results further explain how patients with nephrotic syndrome show responsiveness to ACTH treatment by depressing EGFR signaling through activation of the MC1R receptor and as a consequence restore filtration barrier function by stabilizing the podocyte actin cytoskeleton.

2019-11-12 | PXD009198 | Pride

Basal Epidermis from UVB-irradiated Mc1r and Kit mutants

Project description:Total RNA was extracted from the basal epidermis derived from UVB-irradiated P2.5 normal (Mc1r+/Mc1r+; Kit+/Kit+), Mc1r-mutant (Mc1re/Mc1re) and Kit-mutant (Kit/W-v/Kit/W-v) mice. Biological replicates (cy5) were labelled and co-hybridized with a reference RNA sample (cy3) to a 35K mouse cDNA microarray. A reference experiement design type is where all samples are compared to a common reference. Keywords: reference_design

2007-07-19 | GSE7778 | GEO

MC1R Basis of Melanoma - Parkinson’s Link and Neuroprotective Potential of MC1R

Project description:MC1R Basis of Melanoma - Parkinson’s Link and Neuroprotective Potential of MC1R

| PRJNA671209 | ENA