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Longitudinal study of DNA methylation changes during mouse pregnancy

ABSTRACT: Aging is classically conceptualized as an ever-increasing trajectory of damage accumulation and loss of function, leading to increases in morbidity and mortality. However, recent in vitro studies have raised the possibility of age reversal. We characterized several models in which biological age, assessed primarily through analysis of DNA methylation, undergoes reversible changes. Pregnancy is one such example.

ORGANISM(S): Mus musculus Rattus norvegicus Homo sapiens

PROVIDER: GSE224352 | GEO | 2023/04/21

REPOSITORIES: GEO

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Generalized reversal of glial and neurovascular cell transcriptomic aging signatures by glucagon-like peptide-1 receptor agonist

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