Transcriptomics

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MRNA and lncRNA profiling of mice spleens inoculated with group ACYW135 meningococcal polysaccharide vaccine


ABSTRACT: Group ACYW135 meningococcal polysaccharide vaccine (MPV-ACYW135) is a classical common vaccine used to prevent Neisseria meningitidis serogroup A, C, Y, W135. Although immunological research on MPV has been relatively complete in the past few decades, studies on the vaccine at the transcriptional levels are still limited. In the present study, mRNAs and lncRNAs related to immunity were screened from spleens of mice inoculated with MPV-ACYW135 and compared with the control group to identify the effect and mechanism of these mRNAs and lncRNAs on the immune response. A comprehensive analysis of mRNAs and lncRNAs between MPV group and control group was performed by RNA-seq with bioinformatics.

ORGANISM(S): Mus musculus

PROVIDER: GSE224584 | GEO | 2023/08/30

REPOSITORIES: GEO

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