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Genome-wide maps of chromatin state changes in bone marrow derived macrophages (BMDMs) isolated from Baf60a KO or WT mice

ABSTRACT: Bone marrow cells from Baf60a KO or WT mice were differentiated into BMDMs and treated with or without oxLDL for 48h.

ORGANISM(S): Mus musculus

PROVIDER: GSE224666 | GEO | 2023/09/29

REPOSITORIES: GEO

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Genome-wide maps of chromatin accessibility changes in bone marrow derived macrophages (BMDMs) isolated from Baf60a KO or WT mice

Project description:Bone marrow cells from Baf60a KO or WT mice were differentiated into BMDMs and treated with or without oxLDL for 48h.

2023-09-29 | GSE224667 | GEO

Transcriptome analysis of bone marrow derived macrophages (BMDMs) isolated from C57 mice

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2023-09-29 | GSE224664 | GEO

Genome-wide maps of chromatin state changes in bone marrow derived macrophages (BMDMs) isolated from Baf60a KO or WT mice

Project description:Genome-wide maps of chromatin state changes in bone marrow derived macrophages (BMDMs) isolated from Baf60a KO or WT mice

| PRJNA934489 | ENA

Genome-wide maps of chromatin accessibility changes in bone marrow derived macrophages (BMDMs) isolated from Baf60a KO or WT mice

Project description:Genome-wide maps of chromatin accessibility changes in bone marrow derived macrophages (BMDMs) isolated from Baf60a KO or WT mice

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Genome-wide maps of chromatin state and RNA-seq in WT and Dnmt3a KO BMDMs (bone marrow derived macrophages) [RNA-seq]

Project description:To identify soluble factors released from Dnmt3a KO macrophages that might drive differences in osteoclast differentiation, we performed RNA sequencing on unstimulated BMDMs from WT and Dnmt3a KO mice. To investigate the mechanistic basis for the inflammatory phenotype. of myeloid cells with loss of Dnmt3a,we performed reduced representation bisulfite sequencing (RRBS) on Dnmt3a KO and WT BMDMs to assess methylation changes. Concurrently, we performed ATAC-sequencing (ATAC-seq) to assess differences in chromatin accessibility between WT and Dnmt3a KO BMDMs in the context of changes in methylation. We performed chromatin immunoprecipitation sequencing (CHIP-seq) for Irf3 and Rela based on ATAC-seq analysis.

2021-10-07 | GSE183480 | GEO

Genome-wide maps of chromatin state and RNA-seq in WT and Dnmt3a KO BMDMs (bone marrow derived macrophages) [RRBS, ATAC-seq, CHIP-seq]

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The proteomic of IL-4 treated BMDMs from Wt and Elp3 KO mice

Project description:This experiement aims to know what the differences of protein translation are in the bone marrow derived macro-phages(BMDMs) from WT mice and Elp3 KO mice. We treated the BMDMs with or without IL-4 for 4 hours.

2022-09-12 | PXD033962 | Pride

Transcriptome analysis in adipose tissues of BAF60a knockout mice

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BAF60a deficiency uncouples chromatin accessibility and cold sensitivity from white fat browning

Project description:Brown and beige fat share a remarkably similar transcriptional program that supports fuel oxidation and thermogenesis. The chromatin-remodeling machinery that governs genome accessibility and renders adipocytes poised for thermogenic activation remains elusive. Here we found that BAF60a, a subunit of the SWI/SNF chromatin-remodeling complexes, serves an indispensible role in cold-induced thermogenesis in brown fat. BAF60a maintains chromatin accessibility for key thermogenic genes in close proximity to PPARg and EBF2 binding sites. Surprisingly, fat-specific BAF60a inactivation triggers more pronounced browning of inguinal white adipose tissue that is linked to induction of MC2R, a receptor for the pituitary hormone ACTH. Elevated MC2R expression sensitizes adipocytes and BAF60a-deficient adipose tissue to thermogenic activation in response to ACTH stimulation. These observations reveal an unexpected dichotomous role of BAF60a-mediated chromatin remodeling in transcriptional control of brown and beige gene programs and illustrate a pituitary-adipose signaling axis in the control of thermogenesis.

2020-02-20 | GSE128747 | GEO

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