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Genome-wide maps of chromatin accessibility changes in bone marrow derived macrophages (BMDMs) isolated from Baf60a KO or WT mice

ABSTRACT: Bone marrow cells from Baf60a KO or WT mice were differentiated into BMDMs and treated with or without oxLDL for 48h.

ORGANISM(S): Mus musculus

PROVIDER: GSE224667 | GEO | 2023/09/29

REPOSITORIES: GEO

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Genome-wide maps of chromatin state changes in bone marrow derived macrophages (BMDMs) isolated from Baf60a KO or WT mice

Project description:Bone marrow cells from Baf60a KO or WT mice were differentiated into BMDMs and treated with or without oxLDL for 48h.

2023-09-29 | GSE224666 | GEO

Transcriptome analysis of bone marrow derived macrophages (BMDMs) isolated from C57 mice

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Genome-wide maps of chromatin accessibility changes in bone marrow derived macrophages (BMDMs) isolated from Baf60a KO or WT mice

Project description:Genome-wide maps of chromatin accessibility changes in bone marrow derived macrophages (BMDMs) isolated from Baf60a KO or WT mice

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Genome-wide maps of chromatin state changes in bone marrow derived macrophages (BMDMs) isolated from Baf60a KO or WT mice

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BAF60a deficiency uncouples chromatin accessibility and cold sensitivity from white fat browning

Project description:Brown and beige fat share a remarkably similar transcriptional program that supports fuel oxidation and thermogenesis. The chromatin-remodeling machinery that governs genome accessibility and renders adipocytes poised for thermogenic activation remains elusive. Here we found that BAF60a, a subunit of the SWI/SNF chromatin-remodeling complexes, serves an indispensible role in cold-induced thermogenesis in brown fat. BAF60a maintains chromatin accessibility for key thermogenic genes in close proximity to PPARg and EBF2 binding sites. Surprisingly, fat-specific BAF60a inactivation triggers more pronounced browning of inguinal white adipose tissue that is linked to induction of MC2R, a receptor for the pituitary hormone ACTH. Elevated MC2R expression sensitizes adipocytes and BAF60a-deficient adipose tissue to thermogenic activation in response to ACTH stimulation. These observations reveal an unexpected dichotomous role of BAF60a-mediated chromatin remodeling in transcriptional control of brown and beige gene programs and illustrate a pituitary-adipose signaling axis in the control of thermogenesis.

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The proteomic of IL-4 treated BMDMs from Wt and Elp3 KO mice

Project description:This experiement aims to know what the differences of protein translation are in the bone marrow derived macro-phages(BMDMs) from WT mice and Elp3 KO mice. We treated the BMDMs with or without IL-4 for 4 hours.

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Transcriptome analysis in adipose tissues of BAF60a knockout mice

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Kinetics of LPS induction in wt and Cop1-ko BMDMs

Project description:Bone marrow was extracted from mice that are COP1-wt Rosa26-CreERT2 or COP1-floxed Rosa26-CreERT2 BMDMs were obtained by culturing bone marrow precursors in media containing 20% of supernatant from L929 cells. At day 4 of differentiation 4-OHT was added at 1uM to induce deletion of COP1 in BMDMs derived from COP1-floxed mice. At day 7 of differentiation, BMDMs were treated with 100 ng/ml of LPS or not. BMDMs were directly harvested in lysis buffer (from Qiagen RNeasy mini kit) at different time points (0h, 2.5h, 2.5h, 4h, 6h, 9h and 13h) following LPS stimulation. Three BMDMs preparations per group: G1: BMDMs from COP1-wt mice (expressing the wt allele of COP1) CRE positive. G2: BMDMs from COP1-floxed mice (expressing the floxed allele of COP1) CRE positive

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PolyI:C stimulation of KO vs. WT BMDMs

Project description:Primary murine bone marrow derived macrophages (BMDMs) of Setdb2GT/GT and WT mice were stimulated with polyI:C and harvested at 0, 2 and 8h. Everything with biological triplicates (=cells from 3 individual mice per condition)

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