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Genome-wide maps of chromatin accessibility changes in bone marrow derived macrophages (BMDMs) isolated from Baf60a KO or WT mice

ABSTRACT: Genome-wide maps of chromatin accessibility changes in bone marrow derived macrophages (BMDMs) isolated from Baf60a KO or WT mice

PROVIDER: PRJNA934488 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR23353301_1.fastq.gz	Fastqsanger.gz
	SRR23353301_2.fastq.gz	Fastqsanger.gz
	SRR23353302_1.fastq.gz	Fastqsanger.gz
	SRR23353302_2.fastq.gz	Fastqsanger.gz
	SRR23353303_1.fastq.gz	Fastqsanger.gz

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Genome-wide maps of chromatin accessibility changes in bone marrow derived macrophages (BMDMs) isolated from Baf60a KO or WT mice

Project description:Bone marrow cells from Baf60a KO or WT mice were differentiated into BMDMs and treated with or without oxLDL for 48h.

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Genome-wide maps of chromatin state changes in bone marrow derived macrophages (BMDMs) isolated from Baf60a KO or WT mice

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Genome-wide maps of chromatin state changes in bone marrow derived macrophages (BMDMs) isolated from Baf60a KO or WT mice

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BAF60a deficiency uncouples chromatin accessibility and cold sensitivity from white fat browning

Project description:Brown and beige fat share a remarkably similar transcriptional program that supports fuel oxidation and thermogenesis. The chromatin-remodeling machinery that governs genome accessibility and renders adipocytes poised for thermogenic activation remains elusive. Here we found that BAF60a, a subunit of the SWI/SNF chromatin-remodeling complexes, serves an indispensible role in cold-induced thermogenesis in brown fat. BAF60a maintains chromatin accessibility for key thermogenic genes in close proximity to PPARg and EBF2 binding sites. Surprisingly, fat-specific BAF60a inactivation triggers more pronounced browning of inguinal white adipose tissue that is linked to induction of MC2R, a receptor for the pituitary hormone ACTH. Elevated MC2R expression sensitizes adipocytes and BAF60a-deficient adipose tissue to thermogenic activation in response to ACTH stimulation. These observations reveal an unexpected dichotomous role of BAF60a-mediated chromatin remodeling in transcriptional control of brown and beige gene programs and illustrate a pituitary-adipose signaling axis in the control of thermogenesis.

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Transcriptome analysis in adipose tissues of BAF60a knockout mice

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Project description:We report the application of sequencing technology for high-throughput profiling of mRNA m6A methylation in mice BMDMs with or without PBS treatment. By obtaining over thirty billion bases of sequence from m6A antibody immunoprecipitated mRNA, we generated m6A methylation maps of mouse BMDMs in the presence or absence of LPS. We find that SOCS1 mRNA methylation is robustly enhanced by LPS treatment in WT BMDMs, leading to the increase of SOCS1 expression. However, LPS challenge fails to increase SOCS1 expression in the M14-/- BMDMs, indicating m6A modification plays a cirital role in the SOCS1 expression. This study provides a framework for the application of comprehensive mRNA m6A profiling towards characterization of BMDMs.

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Genome-wide maps of chromatin state and RNA-seq in WT and Dnmt3a KO BMDMs (bone marrow derived macrophages) [RNA-seq]

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