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RNASeq data from OMP-52M51 acute treated T-ALL PDX mice

ABSTRACT: We recently demonstrated that a human Notch1-specific neutralizing antibody (OMP-52M51) was very effective in T-ALL patient derived xenografts (PDX) bearing NOTCH1/FBW7 mutations. To evaluate the transcriptomic downstream effects of anti-NOTCH1 therapy, we perform RNA-Seq analysis in leukemia cells derived from PDTALL46 PDX mice after an acute treatment with control Ab or OMP-52M51.

ORGANISM(S): Homo sapiens

PROVIDER: GSE224988 | GEO | 2023/09/13

REPOSITORIES: GEO

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