Radiation-induced Circulating microRNAs predict cardiac dysfunction after radiotherapy

ABSTRACT: Patients treated with radiotherapy to the chest region are at risk of cardiac sequelae, however, identification of those with greatest risk of complications remains difficult. Here, we sought to determine whether short-term changes in circulating miRNA expression are related to measures of cardiac dysfunction in follow-up. miRNA expression analysis in the primary group showed marked changes in serum miRNAs immediately after RT compared to baseline. miRNAs with increased expression correlated positively with cardiopulmonary dose-volume histogram metrics, while those with decreased expression exhibited negative correlations.

ORGANISM(S): Homo sapiens

PROVIDER: GSE225243 | GEO | 2023/05/07

REPOSITORIES: GEO