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AP-1 signaling modulates cardiac fibroblast stress responses

ABSTRACT: This study aimed to evaluate the genomic effects of single nucleotide polymorphisms (SNPs) at the 9p21 locus that are clinically correlated with heart disease. We performed ATAC sequencing on iPSC-derived cardiac fibroblasts and found large differences in AP-1 and GATA family motifs between cells containing the SNPs and those lacking them.

ORGANISM(S): Homo sapiens

PROVIDER: GSE225736 | GEO | 2023/12/13

REPOSITORIES: GEO

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