Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Genomic adaptation underlies nutrient-driven reprogramming in malaria parasite [tRNA-Seq starvation]

ABSTRACT: We aimed to characterize the change in anti-codon pool upon acute amio acid depletion (6 hours of total depletion)

ORGANISM(S): Plasmodium falciparum

PROVIDER: GSE226630 | GEO | 2023/05/15

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Genomic adaptation underlies nutrient-driven reprogramming in malaria parasite [tRNA-Seq time series]

Project description:We aimed to simultaneously characterize the dynamics of the codon and anti-codon pools during the intraerythrocytic developmental cycle

2023-05-15 | GSE226631 | GEO

Genomic adaptation underlies nutrient-driven reprogramming in malaria parasite [RNA-Seq]

Project description:We aimed to simultaneously characterize the dynamics of the codon and anti-codon pools during the intraerythrocytic developmental cycle

2023-05-15 | GSE226629 | GEO

Genomic adaptation underlies nutrient-driven reprogramming in malaria parasite [PolySeq]

Project description:We aimed to compare the polysome profiles of parasites upon acute amino acid starvation (6 hours of total depletion)

2023-05-15 | GSE226628 | GEO

Genomic adaptation underlies nutrient-driven reprogramming in malaria parasite [tRNA-Seq starvation]

Project description:Genomic adaptation underlies nutrient-driven reprogramming in malaria parasite [tRNA-Seq starvation]

| PRJNA940842 | ENA

Genomic adaptation underlies nutrient-driven reprogramming in malaria parasite [tRNA-Seq time series]

Project description:Genomic adaptation underlies nutrient-driven reprogramming in malaria parasite [tRNA-Seq time series]

| PRJNA940841 | ENA

Genomic adaptation underlies nutrient-driven reprogramming in malaria parasite [PolySeq]

Project description:Genomic adaptation underlies nutrient-driven reprogramming in malaria parasite [PolySeq]

| PRJNA940844 | ENA

Genomic adaptation underlies nutrient-driven reprogramming in malaria parasite [RNA-Seq]

Project description:Genomic adaptation underlies nutrient-driven reprogramming in malaria parasite [RNA-Seq]

| PRJNA940843 | ENA

Nutrient sensing modulates malaria parasite virulence.

Project description:This SuperSeries is composed of the SubSeries listed below.

2017-07-14 | GSE69629 | GEO

Nutrient sensing modulates malaria parasite virulence.

Project description:The lifestyle of intracellular pathogens, such as malaria parasites, is intimately connected to that of their host, primarily for nutrient supply. Nutrients act not only as primary sources of energy but also as regulators of gene expression, metabolism and growth, through various signalling networks that enable cells to sense and adapt to varying environmental conditions. Canonical nutrient-sensing pathways are presumed to be absent from the causative agent of malaria, Plasmodium, thus raising the question of whether these parasites can sense and cope with fluctuations in host nutrient levels. Here we show that Plasmodium blood-stage parasites actively respond to host dietary calorie alterations through rearrangement of their transcriptome accompanied by substantial adjustment of their multiplication rate. A kinome analysis combined with chemical and genetic approaches identified KIN as a critical regulator that mediates sensing of nutrients and controls a transcriptional response to the host nutritional status. KIN shares homology with SNF1/AMPKα, and yeast complementation studies suggest that it is part of a functionally conserved cellular energy-sensing pathway. Overall, these findings reveal a key parasite nutrient-sensing mechanism that is critical for modulating parasite replication and virulence.

| S-EPMC5511512 | biostudies-literature

Start codon-associated ribosomal frameshifting mediates nutrient stress adaptation

Project description:A translating ribosome is typically thought to follow the reading frame defined by the selected start codon. Using super-resolution ribosome profiling, here we report pervasive out-of-frame translation from the start codon. Unlike programmable frameshifting during elongation, start codon-associated ribosome frameshifting (SCARF) stems from the slippage of the initiating ribosome. Using a massively paralleled reporter assay, we uncovered sequence elements acting as SCARF enhancers or repressors, implying that start codon recognition is coupled with reading frame fidelity. This finding explains thousands of mass spectrometry spectra unannotated from human proteome. Mechanistically, we find that the eukaryotic initiation factor 5B (eIF5B) maintains the reading frame fidelity during the transition from initiation to elongation. Intriguingly, amino acid starvation induces SCARF by proteasomal degradation of eIF5B. The stress-induced SCARF products provide a degradative source to mitigate amino acid scarcity during starvation. Our findings illustrate the beneficial effect of divergent translation in nutrient stress adaptation.

2023-03-01 | GSE184825 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data