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Genomic adaptation underlies nutrient-driven reprogramming in malaria parasite [tRNA-Seq time series]

ABSTRACT: We aimed to simultaneously characterize the dynamics of the codon and anti-codon pools during the intraerythrocytic developmental cycle

ORGANISM(S): Plasmodium falciparum

PROVIDER: GSE226631 | GEO | 2023/05/15

REPOSITORIES: GEO

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Genomic adaptation underlies nutrient-driven reprogramming in malaria parasite [RNA-Seq]

Project description:We aimed to simultaneously characterize the dynamics of the codon and anti-codon pools during the intraerythrocytic developmental cycle

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Genomic adaptation underlies nutrient-driven reprogramming in malaria parasite [tRNA-Seq starvation]

Project description:We aimed to characterize the change in anti-codon pool upon acute amio acid depletion (6 hours of total depletion)

2023-05-15 | GSE226630 | GEO

Genomic adaptation underlies nutrient-driven reprogramming in malaria parasite [PolySeq]

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Genomic adaptation underlies nutrient-driven reprogramming in malaria parasite [tRNA-Seq time series]

Project description:Genomic adaptation underlies nutrient-driven reprogramming in malaria parasite [tRNA-Seq time series]

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Genomic adaptation underlies nutrient-driven reprogramming in malaria parasite [tRNA-Seq starvation]

Project description:Genomic adaptation underlies nutrient-driven reprogramming in malaria parasite [tRNA-Seq starvation]

| PRJNA940842 | ENA

Genomic adaptation underlies nutrient-driven reprogramming in malaria parasite [PolySeq]

Project description:Genomic adaptation underlies nutrient-driven reprogramming in malaria parasite [PolySeq]

| PRJNA940844 | ENA

Genomic adaptation underlies nutrient-driven reprogramming in malaria parasite [RNA-Seq]

Project description:Genomic adaptation underlies nutrient-driven reprogramming in malaria parasite [RNA-Seq]

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Nutrient sensing modulates malaria parasite virulence.

Project description:This SuperSeries is composed of the SubSeries listed below.

2017-07-14 | GSE69629 | GEO

T4_bisthiazolium effect on the malaria parasite transcriptome

Project description:Choline analogs represent a novel class of antimalarial compounds with strong potency against drug-sensitive and resistant P. falciparum. Although, these drugs are presumed to target proteins within lipid biosynthesis pathways; their complete mechanism of action and the parasite’s compensatory response remain to be elucidated. We have applied transcriptional profiling to characterize the global response to the choline analog T4 during the P. falciparum intraerythrocytic life cycle Keywords: Trascriptome analysis of Plasmodium falciparum in response to external stimuli using the affymetrix platform GPL3575

2007-07-31 | GSE4582 | GEO

Nutrient sensing modulates malaria parasite virulence.

Project description:The lifestyle of intracellular pathogens, such as malaria parasites, is intimately connected to that of their host, primarily for nutrient supply. Nutrients act not only as primary sources of energy but also as regulators of gene expression, metabolism and growth, through various signalling networks that enable cells to sense and adapt to varying environmental conditions. Canonical nutrient-sensing pathways are presumed to be absent from the causative agent of malaria, Plasmodium, thus raising the question of whether these parasites can sense and cope with fluctuations in host nutrient levels. Here we show that Plasmodium blood-stage parasites actively respond to host dietary calorie alterations through rearrangement of their transcriptome accompanied by substantial adjustment of their multiplication rate. A kinome analysis combined with chemical and genetic approaches identified KIN as a critical regulator that mediates sensing of nutrients and controls a transcriptional response to the host nutritional status. KIN shares homology with SNF1/AMPKα, and yeast complementation studies suggest that it is part of a functionally conserved cellular energy-sensing pathway. Overall, these findings reveal a key parasite nutrient-sensing mechanism that is critical for modulating parasite replication and virulence.

| S-EPMC5511512 | biostudies-literature

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