Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Genomic adaptation underlies nutrient-driven reprogramming in malaria parasite [tRNA-Seq starvation]

ABSTRACT: Genomic adaptation underlies nutrient-driven reprogramming in malaria parasite [tRNA-Seq starvation]

PROVIDER: PRJNA940842 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR23698650.fastq.gz	Fastqsanger.gz
	SRR23698651.fastq.gz	Fastqsanger.gz
	SRR23698652.fastq.gz	Fastqsanger.gz
	SRR23698653.fastq.gz	Fastqsanger.gz
	SRR23698654.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 9

Similar Datasets

Genomic adaptation underlies nutrient-driven reprogramming in malaria parasite [tRNA-Seq time series]

Project description:Genomic adaptation underlies nutrient-driven reprogramming in malaria parasite [tRNA-Seq time series]

| PRJNA940841 | ENA

Genomic adaptation underlies nutrient-driven reprogramming in malaria parasite [tRNA-Seq starvation]

Project description:We aimed to characterize the change in anti-codon pool upon acute amio acid depletion (6 hours of total depletion)

2023-05-15 | GSE226630 | GEO

Genomic adaptation underlies nutrient-driven reprogramming in malaria parasite [PolySeq]

Project description:Genomic adaptation underlies nutrient-driven reprogramming in malaria parasite [PolySeq]

| PRJNA940844 | ENA

Genomic adaptation underlies nutrient-driven reprogramming in malaria parasite [PolySeq]

Project description:We aimed to compare the polysome profiles of parasites upon acute amino acid starvation (6 hours of total depletion)

2023-05-15 | GSE226628 | GEO

Genomic adaptation underlies nutrient-driven reprogramming in malaria parasite [RNA-Seq]

Project description:Genomic adaptation underlies nutrient-driven reprogramming in malaria parasite [RNA-Seq]

| PRJNA940843 | ENA

Genomic adaptation underlies nutrient-driven reprogramming in malaria parasite [tRNA-Seq time series]

Project description:We aimed to simultaneously characterize the dynamics of the codon and anti-codon pools during the intraerythrocytic developmental cycle

2023-05-15 | GSE226631 | GEO

Nutrient sensing modulates malaria parasite virulence.

Project description:Nutrient sensing modulates malaria parasite virulence.

| PRJNA286025 | ENA

tRNA senses cellular nutrient status and senescence via amino acid acylation

Project description:We profiled the cellular tRNA charging landscape using next-generation sequencing and identified a subset of tRNA that sense nutrients. The charging levels of tRNAGln were exclusively and significantly decreased in response to amino acid starvation.

2022-11-30 | GSE157510 | GEO

Genomic adaptation underlies nutrient-driven reprogramming in malaria parasite [RNA-Seq]

Project description:We aimed to simultaneously characterize the dynamics of the codon and anti-codon pools during the intraerythrocytic developmental cycle

2023-05-15 | GSE226629 | GEO

Misactivation of multiple starvation responses in yeast by loss of tRNA modifications

Project description:Previously, combined loss of specific anticodon loop modifications was shown to impair the function of distinct tRNAs in Saccharomyces cerevisiae. Surprisingly, each scenario resulted in shared cellular phenotypes, the basis of which is unclear. To investigate how loss of different tRNA modifications can induce overlapping phenotypes, we characterized global transcription patterns of modification mutants with defects in either tRNAGlnUUG or tRNALysUUU function. We observe that the mutants share an inappropriate induction of multiple starvation responses, including derepression of glucose and nitrogen catabolite-repressed genes as well as improper activation of amino acid biosynthesis and autophagy genes, all of which occur prematurely and inadequately in exponential growth phase. We further demonstrate that improper responses to starvation as well as the propensity of the tRNA modification mutants to form protein aggregates are diminished upon overexpression of tRNAGlnUUG or tRNALysUUU, the tRNA species that lack the modifications of interest. Hence, our data suggest that global alterations in mRNA translation and proteostasis (rather than codon specific defects in translation) account for the transcriptional stress signatures that are commonly triggered by loss of anticodon modifications in different tRNAs.

2020-04-01 | GSE141887 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data