Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Nasopharyngeal lymphatic plexus serves as a central hub for drainage of cerebrospinal fluid [Aged]

ABSTRACT: To investigate the heterogeneity of murine nasopharyngeal LECs, CD31+ PDPN+ LECs from the aged mouse nasopharynx were FACS sorted and single-cell RNA seq was performed

ORGANISM(S): Mus musculus

PROVIDER: GSE227324 | GEO | 2023/04/01

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Nasopharyngeal lymphatic plexus serves as a central hub for drainage of cerebrospinal fluid [Adult]

Project description:To investigate the heterogeneity of murine nasopharyngeal LECs, CD31+ PDPN+ LECs from the adult mouse nasopharynx were FACS sorted and single-cell RNA seq was performed

2023-04-01 | GSE227311 | GEO

Nasopharyngeal lymphatic plexus serves as a central hub for drainage of cerebrospinal fluid [Adult]

Project description:Nasopharyngeal lymphatic plexus serves as a central hub for drainage of cerebrospinal fluid [Adult]

| PRJNA944625 | ENA

Nasopharyngeal lymphatic plexus serves as a central hub for drainage of cerebrospinal fluid [Aged]

Project description:Nasopharyngeal lymphatic plexus serves as a central hub for drainage of cerebrospinal fluid [Aged]

| PRJNA944651 | ENA

human nasopharyngeal metagenome

Project description:Human nasopharynx Metagenome

| PRJNA229922 | ENA

Transcriptional profiling of melanoma-associated lymphatic endothelial cells (LECs)

Project description:Objective was to uncover the transcriptional changes occuring in melanoma-associated LECs relative to LECs of naïve skin. To investigate the transcriptional changes in LECs during tumor development, RNA was extracted from LECs sorted from naïve skin and BPC (Tyr::Cre-ER, BRafV600E) murine melanomas and bulk RNA-seq performed. Naïve skin LECs were collected from 3 mice and tumor-associated LECs collected from 4 mice.

2023-01-20 | GSE203307 | GEO

Transcription profiling of human intestinal versus dermal lymphatic endothelial cells

Project description:In this analysis we have compared the gene expression profiles of lymphatic endothelial cells (LECs) isolated from human intestine (iLECs) versus LECs from human skin (dLECs).

2010-02-03 | E-MEXP-2452 | biostudies-arrayexpress

Activated Notch-induced transcriptional profile modulation in human primary dermal lymphatic endothelial cells

Project description:Human Notch1 intracellular domain (NICD) was overexpressed in human primary lymphatic endothelial cells (LECs) for 10 and 24 hours by adenovirus. A GFP-control adenovirus-infected cells (24hours) and uninfected cells were also analysed as controls. Total RNAs were harvested and subjected to Affymetrix U133A microarray. Human primary lymphatic endothelial cells (LECs) were isolated from human foreskin and cultured and expanded to population passages 5~6. Healthy subconfluent primary LECs were infected with adenovirus expressing human Notch1 intracellular domain (NICD) for 10 or 24 hours. In parallel, LECs were also infected with a GFP-expressing control adenovirus for 24 hours. Uninfected LECs were also used as a negative control in the same experiments

2010-03-20 | E-GEOD-20978 | biostudies-arrayexpress

Gene expression data of nasopharyngeal carcinoma (NPC) cell and Podoplanin (PDPN) siRNA treatment

Project description:Podoplanin, a transmembrane sialomucin-like glycoprotein, is now widely used as a marker for lymphatic endothelial cells and fibroblastic reticular cells in lymphoid organs, but its study in nasopharyngeal carcinoma (NPC) is still limited. The aims of this study were t characterize the role of PDPN in NPC. Our results showed that PDPN was expressed in most TW01 NPC cells. PDPN knockdown by siRNA decreased NPC cell proliferation, migration, and invasion. Knocking down PDPN results in suppression of NPC cell proliferation, migration, and invasion. PDPN may serve as a potential chemotherapeutic target for NPC treatment in the future.

2019-03-19 | GSE128502 | GEO

Podoplanin-expressing macrophages (PoEMs) promote lymphangiogenesis and favour lymphatic metastasis in breast cancer

Project description:RNAseq was performed on PoEMs (CD11b+, F4/80+, PDPN+) vs. non-PoEMs (CD11b+, F4/80+, PDPN-) sorted from orthotopically inoculated 4T1 tumors in WT mice.

2019-10-03 | GSE126722 | GEO

Intrathecal [<sup>64</sup>Cu]Cu-albumin PET reveals age-related decline of lymphatic drainage of cerebrospinal fluid.

Project description:Age-related cognitive decline is associated with dysfunctional lymphatic drainage of cerebrospinal fluid (CSF) through meningeal lymphatic vessels. In this study, intrathecal [64Cu]Cu-albumin positron emission tomography (PET) was applied in mice to evaluate lymphatic drainage of CSF and its variation with age. [64Cu]Cu-albumin PET was performed at multiple time points after intrathecal injection of [64Cu]Cu-albumin at an infusion rate of 700 nl/min in adult and aged mice (15-25 months old). CSF clearance and paravertebral lymph nodes were quantified after injection and during the stationary phase. Stationary phase of the next day followed the initial perturbed state by injection of 6 ul (1/7 of total CSF volume) and CSF clearance half-time from the subarachnoid space was 93.4 ± 19.7 and 123.3 ± 15.6 min in adult and aged mice (p = 0.01), respectively. While the % injected dose of CSF space were higher, the activity of the paravertebral lymph nodes were lower in the aged mice on the next day. [64Cu]Cu-albumin PET enabled us to quantify CSF-lymphatic drainage across all levels of brain spinal cords and to visualize and quantify lymph node activity due to CSF drainage. [64Cu]Cu-albumin PET revealed the age-related decrease of the lymphatic drainage of CSF due to this decreased drainage from the subarachnoid space, especially during the stationary phase, in aged mice.

| S-EPMC10412645 | biostudies-literature

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data