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Gene expression profiling

ABSTRACT: A number of homeobox genes have been found to be implicated in the development of various cancers. Here, we investigated the role of engrailed 2 (EN2), a member of the homeobox gene superfamily, in non-small cell lung cancer

ORGANISM(S): Homo sapiens

PROVIDER: GSE228854 | GEO | 2023/12/31

REPOSITORIES: GEO

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Role of engrailed 2 (EN2) in esophageal squamous cell carcinoma

Project description:A number of homeobox genes have been found to be implicated in the development of various cancers. Here, we investigated the role of engrailed 2 (EN2), a member of the homeobox gene superfamily, in esophageal squamous cell carcinoma

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Lineage-specific function of Engrailed-2 in the progression of chronic myelogenous leukemia to T cell blast crisis

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Project description:Engrailed homeoproteins are expressed in adult dopaminergic neurons of the substantia nigra. In Engrailed1 heterozygous mice, these neurons start dying at 6 weeks, are more sensitive to oxidative stress and progressively develop traits similar to those observed following an acute and strong oxidative stress inflected to wild-type neurons. These changes include DNA strand breaks and the modification (intensity and distribution) of several nuclear and nucleolar heterochromatin marks. Engrailed1 and Engrailed2 are biochemically equivalent transducing proteins previously used to antagonize dopaminergic neuron death in Engrailed heterozygous mice and in mouse models of Parkinson disease. Accordingly, we show that, following an acute oxidative stress, a single Engrailed2 injection restores all nuclear and nucleolar heterochromatin marks, decreases the number of DNA strand breaks and protects dopaminergic neurons against apoptosis. RNA-seq data for differentially expressed genes in the SNpc of En1+/- mice, En2 infused mice and 6-OHDA/En2 injection experiments.

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Role of engrailed 2 (EN2) in esophageal squamous cell carcinoma

Project description:Role of engrailed 2 (EN2) in esophageal squamous cell carcinoma

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