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Rational designs of Cas12a nuclease with the improved targeting specificity at both the proximal and distal region from the PAM

ABSTRACT: Our findings provide a novel version of AsCas12a variant with low off-target effects, especially capable of dealing with the high off-targeting at the distal region from the PAM.

ORGANISM(S): Homo sapiens

PROVIDER: GSE229888 | GEO | 2023/04/17

REPOSITORIES: GEO

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