Transcriptomics

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Synthetically mannosylated antigens induce antigen-specific humoral tolerance and prevent anti-drug antibody responses to immunogenic biologics


ABSTRACT: The purpose of this study were to test the feasibility of using pMan-antigen therapy to induce humoral tolerance. We used OVA as a model protein along with TCR transgenic OT-I and OT-II to study antigen-specific CD4+ T cell phenotypes and transcriptomic responses using RNA-seq readouts.

ORGANISM(S): Mus musculus

PROVIDER: GSE229893 | GEO | 2023/11/02

REPOSITORIES: GEO

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