Synthetically mannosylated antigens induce antigen-specific humoral tolerance and prevent anti-drug antibody responses to immunogenic biologics
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ABSTRACT: The purpose of this study were to test the feasibility of using pMan-antigen therapy to induce humoral tolerance. We used OVA as a model protein along with TCR transgenic OT-I and OT-II to study antigen-specific CD4+ T cell phenotypes and transcriptomic responses using RNA-seq readouts.
ORGANISM(S): Mus musculus
PROVIDER: GSE229893 | GEO | 2023/11/02
REPOSITORIES: GEO
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