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Effect of iron exposure on the gene expression profile of human brain vascular pericytes.

ABSTRACT: We hypothesize blood breakdown products present after hemorrhage to be inducers of brain edema via the ferroptosis-induced cell death of pericytes leading to comprimised blood-brain-barrier. RNAseq was applied to investigate the intracellular response of pericytes to iron exposure from cerebral hemorrhage.

ORGANISM(S): Homo sapiens

PROVIDER: GSE230184 | GEO | 2025/03/05

REPOSITORIES: GEO

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Determine the role of ALK5 signaling in human brain pericytes treated with TGFβ.

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