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Genome-wide methylated CpG status in WT and IRF8KO microglia [WGBS]

ABSTRACT: The role of the lineage-determining transcription factor, Interferon regulatory factor (IRF8), in microglia remains elucidated. We report the genome-wide methyl-CpG status in adult wild-type (WT) and IRF8-knockout (IRF8KO) microglia by whole-genome bisulfite-Seq (WGBS). Deep-sequencing and subsequent differential analysis revealed that IRF8KO microglia exhibited a cell-intrinsic methylation profile. Furthermore, the differentially methylated regions showed a significant correlation with IRF8-dependent chromatin accessibility in microglia. This study provides a novel insight into understanding epigenetic regulation in microglia.

ORGANISM(S): Mus musculus

PROVIDER: GSE231404 | GEO | 2023/06/01

REPOSITORIES: GEO

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