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Single-cell transcriptome profiles of wild-type and IRF8KO microglia [scRNA-seq]

ABSTRACT: The role of the lineage-determining transcription factor IRF8 in microglia remains unelucidated. We analyzed the transcriptome diversity of wild-type and IRF8KO microglia. Deep-sequencing and subsequent differential analysis revealed the significance of the IRF8-dependent transcription on microglial heterogeneity and self-renewing. This study provides a novel insight into understanding IRF8-mediated transcriptional programs in microglia.

ORGANISM(S): Mus musculus

PROVIDER: GSE231405 | GEO | 2023/06/01

REPOSITORIES: GEO

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