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Spatiotemporal transcriptomic map of glial cell response in a mouse model of acute brain ischemia

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE233815 | GEO | 2024/11/18

REPOSITORIES: GEO

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Spatiotemporal transcriptomic map of glial cell response in a mouse model of acute brain ischemia [spatial transcriptomics]

Project description:We performed spatial and single-cell transcriptomics on male mouse brains to map out the molecular and cellular processes governing the response to ischemic stroke during the first week after the injury. Focusing on glial cells, we documented their activation, the formation of the glial scar, and significant changes in cell–cell communication patterns. Interestingly, we identified various activated populations of oligodendrocytes that, while similar in their anti-inflammatory properties, differ in their immunogenic and metabolic characteristics. This challenges the long-held belief that oligodendrocytes play a passive role in neuropathologies. Altogether, we present a major contribution to the current understanding of the role of glial cells in stroke pathobiology, comprehensively mapping their acute response and role in the formation of the glial scar.

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Spatiotemporal transcriptomic map of glial cell response in a mouse model of acute brain ischemia [snRNA-Seq]

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Spatiotemporal transcriptomic map of glial cell response in a mouse model of acute brain ischemia [scRNA-Seq]

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Spatiotemporal transcriptomic map of glial cell response in a mouse model of acute brain ischemia [bulk RNA-Seq]

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Spatiotemporal transcriptomic map of glial cell response in a mouse model of acute brain ischemia

Project description:Spatiotemporal transcriptomic map of glial cell response in a mouse model of acute brain ischemia

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Spatiotemporal transcriptomic map of glial cell response in a mouse model of acute brain ischemia [spatial transcriptomics]

Project description:Spatiotemporal transcriptomic map of glial cell response in a mouse model of acute brain ischemia [spatial transcriptomics]

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Spatiotemporal transcriptomic map of glial cell response in a mouse model of acute brain ischemia [snRNA-Seq]

Project description:Spatiotemporal transcriptomic map of glial cell response in a mouse model of acute brain ischemia [snRNA-Seq]

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Spatiotemporal transcriptomic map of glial cell response in a mouse model of acute brain ischemia [scRNA-Seq]

Project description:Spatiotemporal transcriptomic map of glial cell response in a mouse model of acute brain ischemia [scRNA-Seq]

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Spatiotemporal transcriptomic map of glial cell response in a mouse model of acute brain ischemia [bulk RNA-Seq]

Project description:Spatiotemporal transcriptomic map of glial cell response in a mouse model of acute brain ischemia [bulk RNA-Seq]

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Metabolic and Transcriptomic Signatures of the Acute Psychological Stress Response in the Mouse Brain.

Project description:Acute stress response triggers various physiological responses such as energy mobilization to meet metabolic demands. However, the underlying molecular changes in the brain remain largely obscure. Here, we used a brief water avoidance stress (WAS) to elicit an acute stress response in mice. By employing RNA-sequencing and metabolomics profiling, we investigated the acute stress-induced molecular changes in the mouse whole brain. The aberrant expression of 60 genes was detected in the brain tissues of WAS-exposed mice. Functional analyses showed that the aberrantly expressed genes were enriched in various processes such as superoxide metabolism. In our global metabolomic profiling, a total of 43 brain metabolites were significantly altered by acute WAS. Metabolic pathways upregulated from WAS-exposed brain tissues relative to control samples included lipolysis, eicosanoid biosynthesis, and endocannabinoid synthesis. Acute WAS also elevated the levels of branched-chain amino acids, 5-aminovalerates, 4-hydroxy-nonenal-glutathione as well as mannose, suggesting complex metabolic changes in the brain. The observed molecular events in the present study provide a valuable resource that can help us better understand how acute psychological stress impacts neural functions.

| S-EPMC10052811 | biostudies-literature

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