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Spatiotemporal transcriptomic map of glial cell response in a mouse model of acute brain ischemia

ABSTRACT: Spatiotemporal transcriptomic map of glial cell response in a mouse model of acute brain ischemia

PROVIDER: PRJNA978030 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR24781000.fastq.gz	Fastqsanger.gz
	SRR24781001.fastq.gz	Fastqsanger.gz
	SRR24781002.fastq.gz	Fastqsanger.gz
	SRR24781003.fastq.gz	Fastqsanger.gz
	SRR24781004.fastq.gz	Fastqsanger.gz

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Spatiotemporal transcriptomic map of glial cell response in a mouse model of acute brain ischemia [spatial transcriptomics]

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Spatiotemporal transcriptomic map of glial cell response in a mouse model of acute brain ischemia [bulk RNA-Seq]

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Spatiotemporal transcriptomic map of glial cell response in a mouse model of acute brain ischemia [spatial transcriptomics]

Project description:We performed spatial and single-cell transcriptomics on male mouse brains to map out the molecular and cellular processes governing the response to ischemic stroke during the first week after the injury. Focusing on glial cells, we documented their activation, the formation of the glial scar, and significant changes in cell–cell communication patterns. Interestingly, we identified various activated populations of oligodendrocytes that, while similar in their anti-inflammatory properties, differ in their immunogenic and metabolic characteristics. This challenges the long-held belief that oligodendrocytes play a passive role in neuropathologies. Altogether, we present a major contribution to the current understanding of the role of glial cells in stroke pathobiology, comprehensively mapping their acute response and role in the formation of the glial scar.

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Spatiotemporal transcriptomic map of glial cell response in a mouse model of acute brain ischemia [snRNA-Seq]

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Spatiotemporal transcriptomic map of glial cell response in a mouse model of acute brain ischemia [scRNA-Seq]

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Spatiotemporal transcriptomic map of glial cell response in a mouse model of acute brain ischemia [bulk RNA-Seq]

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Spatiotemporal transcriptomic map of glial cell response in a mouse model of acute brain ischemia

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-11-18 | GSE233815 | GEO

A Spatiotemporal Notch Interaction Map from Membrane to Nucleus

Project description:Notch signaling relies on ligand-induced proteolysis to liberate a nuclear effector that drives cell fate decisions. The location and timing of individual steps required for proteolysis and movement of Notch from membrane to nucleus, however, remain unclear. Here, we use proximity labeling with quantitative multiplexed mass spectrometry to monitor the microenvironment of endogenous Notch2 after ligand stimulation in the presence of a gamma secretase inhibitor and then as a function of time after inhibitor removal. Our studies show that gamma secretase cleavage of Notch2 occurs in an intracellular compartment and that formation of nuclear complexes and recruitment of chromatin-modifying enzymes occurs within 45 minutes of inhibitor washout. This work provides a spatiotemporal map of unprecedented detail tracking the itinerary of Notch from membrane to nucleus after activation and identifies molecular events in signal transmission that are potential targets for modulating Notch signaling activity.

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