Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Deletion of KvB2 leads to loss of muscle function in young and old mice

ABSTRACT: To investigate the skeletal muscle function and aging phenotype of KvB2 null mice we utilized the young and old KvB2 KO mice

ORGANISM(S): Mus musculus

PROVIDER: GSE233996 | GEO | 2023/07/01

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Single cell RNA-seq of skeletal muscle from young and old mice

Project description:We report the scRNA-seq of mononuclear cells isolated from skeletal muscle of young and old mice.

2022-05-20 | GSE172410 | GEO

RNA-seq of skeletal muscle of young, old, and senolytics treated mice

Project description:We report RNA-seq of skeletal muscle (quadriceps) of young (6-month), old (24-month), and senolytic (Dasatinib + quercetin) treated mice

2022-05-20 | GSE184348 | GEO

KH_dKO: Simultaneous loss of skeletal muscle myosin heavy chain IIx and IIb causes severe hypoplasia of skeletal muscles in young mice

Project description:Simultaneous loss of skeletal muscle myosin heavy chain IIx and IIb causes severe hypoplasia of skeletal muscles in young mice

2022-11-28 | PXD032244 | JPOST Repository

Expression data from skeletal muscle of young, old and old calorie restricted mice

Project description:We investigated age-related changes in the transcriptional profile of skeletal muscle in 5 month old (young) and 25 month old (old) C57BL/6NHsd mice using high density oligonucleotide arrays (22,690 transcripts probed). We identified 712 transcripts that are differentially expressed in young (5 month old) and old (25-month old) mouse skeletal muscle. Caloric restriction (CR) completely or partially reversed 87% of the changes in expression. Examination of individual genes revealed a transcriptional profile indicative of increased p53 activity in the older muscle. To determine whether the increase in p53 activity is associated with transcriptional activation of apoptotic targets, we performed RT-PCR on four well known mediators of p53-induced apoptosis: puma, noxa, tnfrsf10b and bok. Expression levels for these proapoptotic genes increased significantly with age (P<0.05), while CR significantly lowered expression levels for these genes as compared to control fed old mice (P<0.05). Age-related induction of p53-related genes was observed in multiple tissues, but was not observed in SOD2+/- and GPX4+/- mice, suggesting that oxidative stress does not mediate the observed age-related increase in expression. Western blot analysis confirmed that protein levels for both p21 and GADD45a, two established transcriptional targets of p53, were higher in the older muscle tissue. These observations support a role for p53-mediated apoptotic activity in mammalian aging. Keywords: aging, calorie restriction, muscle, p53

2006-12-01 | GSE6323 | GEO

Comparison of Wild type and Pofut1-deleted skeletal muscle in young and old mice

Project description:Pofut1 is an essential gene that glycosylates proteins containing EGF-like repeats, including Notch Receptors (NotchRs). Work in mice and in Drosophila has shown that O-fucosylation by Pofut1 is required for NotchR ligands to bind to and activate NotchRs. As such, Pofut1 deletion in skeletal myofibers allows for an analysis of potential functions and molecular changes of Pofut1 in skeletal muscle that derive from its expression in skeletal myofibers. In this study we compared gene expression profiles between quadriceps muscles in young (2 month) and old (17 month) mice where Protein O-fucosyltransferase 1 (Pofut1) was deleted specifically in skeletal myofibers via use of a human skeletal alpha actin Cre transgene (Scre) and a loxP flanked Pofut1 gene (SCreFF) and mice which bore the only the Scre transgene but did not have floxed Pofut1 alleles (SCre++).

2017-03-27 | GSE94768 | GEO

RNA-seq of skeletal muscle of young, old, and senolytics treated mice

Project description:RNA-seq of skeletal muscle of young, old, and senolytics treated mice

| PRJNA764199 | ENA

Single cell RNA-seq of skeletal muscle from young and old mice

Project description:Single cell RNA-seq of skeletal muscle from young and old mice

| PRJNA723271 | ENA

16s rRNA-young and old mouse gut microbiota-stroke

Project description:To explore the effects of gut microbiota of young (8 weeks) or old mice (18～20 months) on stroke, feces of young (Y1-Y9) and old mice (O6-O16) were collected and analyzed by 16s rRNA sequencing. Then stroke model was established on young mouse receive feces from old mouse (DOT1-15) and young mouse receive feces from young mouse (DYT1-15). 16s rRNA sequencing were also performed for those young mice received feces from young and old mice.

2021-10-15 | E-MTAB-10837 | biostudies-arrayexpress

Transcription profiles of young and old HSCs

Project description:Here we examine the transriptomes of HSCs from young (2 months) vs old (24 months) mice bone marrow.

2023-02-22 | GSE219092 | GEO

Epigenetic profiles of young vs old HSCs

Project description:Here we examine the chromatin landscapes of HSCs from young (2 months) vs old (24 months) mice bone marrow.

2023-02-22 | GSE219032 | GEO