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RNAseq of periosteal stem/progenitor cells from patients with congenital pseudarthrosis of the tibia

ABSTRACT: Congenital pseudarthrosis of the tibia (CPT) is a severe pediatric disorder affecting children. CPT is characterized by tibial bowing at birth leading to spontaneous fracture and fibrous non-union. Our study showed the presence of biallelic inactivation of the NF1 gene in the periosteum and in periosteal skeletal/stem progenitor cells (pSSPCs) at the pseudarthrosis site.

ORGANISM(S): Homo sapiens

PROVIDER: GSE234071 | GEO | 2024/07/24

REPOSITORIES: GEO

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Single nuclei RNAseq of the human periosteum from patients with congenital pseudarthrosis of the tibia

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