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Pharmacological YAP activation promotes regenerative repair of cutaneous wounds.

ABSTRACT: Chronic cutaneous wounds remain a persistent unmet medical need that decrease expectancy and quality of life. Here, we report that topical application of PY-60, a small molecule activator of the transcriptional coactivator YAP, promotes regenerative repair of cutaneous wounds in pig and human models. Pharmacological YAP activation enacts a reversible pro-proliferative transcriptional program in keratinocytes and dermal cells that results in accelerated re-epithelization and regranulation of the wound bed. These results demonstrate that transient topical administration of a YAP activating agent may represent a generalizable therapeutic approach to treating chronic wounds.

ORGANISM(S): Homo sapiens

PROVIDER: GSE234332 | GEO | 2023/06/11

REPOSITORIES: GEO

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