3D chromatin architecture of drug-tolerant cancer cells at single-cell resolution (scDNA-seq dataset)
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ABSTRACT: Anticancer drug therapy generally elicits the drug tolerance after long-term treatment. Recent studies suggested that 3D chromatin structures of cancer cells were intimately linked to drug resistance. However, 3D chromatin structures in drug-tolerant cancer cells at single-cell resolution haven’t been elucidated. Here we performed single-cell Hi-C (scHi-C) analysis to examine the 3D chromatin structures in three stages of breast cancer cells. Then Single-cell RNA-seq data were integrated with scHi-C data. scDNA-seq data were also been generated.
ORGANISM(S): Homo sapiens
PROVIDER: GSE239435 | GEO | 2024/08/14
REPOSITORIES: GEO
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