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Infiltrating CD8+ T cells exacerbate Alzheimer’s disease pathology in a novel 3D human neuroimmune axis model

ABSTRACT: T cells have been proposed to play a role in Alzheimer’s disease (AD) pathology by infiltrating the brain and interacting with resident cells. Here, we describe a novel three- dimensional (3D) human neuroimmune axis model comprised of human stem cell-derived neurons, astrocytes, and microglia, together with human peripheral immune cells. We used this neuroimmune axis model to examine the infiltration of peripheral immune cells into AD versus control neural-glial cell cultures. Using single-cell RNA- sequencing, we identified that infiltrating T cells into AD cultures led to induction of interferon-gamma and neuroinflammatory-associated pathways in microglial cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE239509 | GEO | 2023/08/14

REPOSITORIES: GEO

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