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Transcriptome analysis reveals key genes and pathways that macrophage of islet in NCD(normal chow feed) or HFD( high fat feed)

ABSTRACT: Our research is helpful to understand the physiological and pathological level changes caused on the macrophages of islet in HFD conditional, to find the different mechanism or signaling pathway compared with NCD

ORGANISM(S): Mus musculus

PROVIDER: GSE239708 | GEO | 2023/08/15

REPOSITORIES: GEO

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Transcriptome analysis reveals key genes and pathways that macrophage of islet in NCD(normal chow feed) or HFD( high fat feed)

Project description:Transcriptome analysis reveals key genes and pathways that macrophage of islet in NCD(normal chow feed) or HFD( high fat feed)

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Genome-wide expression profile of livers from mice fed HFD,SO-HFD or Viv chow [RNAseq]

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Project description:Gene expression in livers of male wild-type (WT) and OGG1-deficient (Ogg1-/-) mice fed either a chow diet or a high-fat diet (HFD) were examined. Mice were fed the diet for 10 weeks prior to tissue collection and were 22 weeks of age at the time of tissue collection. 24 Total samples were analyzed. We generated the following pairwise comparisons using GeneSifter: WT Chow vs Ogg1-/- Chow; WT HFD vs. Ogg1-/- HFD using t-test followed by Benjamini and Hochberg correction. An adjusted p-value less than 0.05 was considered to be statistically significant.

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