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Transcriptome analysis reveals key genes and pathways that macrophage of islet in NCD(normal chow feed) or HFD( high fat feed)

ABSTRACT: Transcriptome analysis reveals key genes and pathways that macrophage of islet in NCD(normal chow feed) or HFD( high fat feed)

PROVIDER: PRJNA1000599 | ENA |

REPOSITORIES: ENA

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Transcriptome analysis reveals key genes and pathways that macrophage of islet in NCD(normal chow feed) or HFD( high fat feed)

Project description:Our research is helpful to understand the physiological and pathological level changes caused on the macrophages of islet in HFD conditional, to find the different mechanism or signaling pathway compared with NCD

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Effect of high-fat diet (HFD) on gene expression in brown adipose tissue (BAT)

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Microarray data, 4 week HFD/NCD, nostim or 16hrstim

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Effect of high-fat diet (HFD) on gene expression in brown adipose tissue (BAT)

Project description:C57BL/6 male mice were fed a standardized NCD or HFD after weaning (4 weeks of age) over a course of 12 weeks. Normal chow diet (NCD) fed animals served as Controls Biotin-labeled cDNA was synthesized using GeneChip Whole Transcript Sense Labeling Assay (Affymetrix) according to vendor’s instructions. After fragmentation, cDNAs were hybridized for 17h at 45°C on Affymetrix Mouse Gene 1.0 ST Arrays. The Arrays were washed and stained in the GeneChip Fluidics Station 450 and scanned on a GeneChip Scanner 3000 7G (Affymetrix). Data intensities were log transformed and normalized with a quantile normalization method using Affymetrix Power Tools. Differentially expressed genes were identified according to statistical evidence indicated by Student's t-test and fold change statistics

2015-06-06 | E-GEOD-69608 | biostudies-arrayexpress

Proteomics of liver from mice fed high fat diet (HFD) or regular chow diet

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2021-10-27 | PXD029280 | Pride

Genome-wide expression profile of livers from mice fed HFD,SO-HFD or Viv chow [RNAseq]

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RNA Sequencing Analysis of the epididymal adipose tissue from Normal Chow, HFD Control and SZ-A-treated HFD mice

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