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Transcriptome analysis reveals key genes and pathways that macrophage of islet in NCD(normal chow feed) or HFD( high fat feed)

ABSTRACT: Transcriptome analysis reveals key genes and pathways that macrophage of islet in NCD(normal chow feed) or HFD( high fat feed)

PROVIDER: PRJNA1000599 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR25469140_1.fastq.gz	Fastqsanger.gz
	SRR25469140_2.fastq.gz	Fastqsanger.gz
	SRR25469141_1.fastq.gz	Fastqsanger.gz
	SRR25469141_2.fastq.gz	Fastqsanger.gz
	SRR25469142_1.fastq.gz	Fastqsanger.gz

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Transcriptome analysis reveals key genes and pathways that macrophage of islet in NCD(normal chow feed) or HFD( high fat feed)

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Project description:C57BL/6 male mice were fed a standardized NCD or HFD after weaning (4 weeks of age) over a course of 12 weeks. Normal chow diet (NCD) fed animals served as Controls Biotin-labeled cDNA was synthesized using GeneChip Whole Transcript Sense Labeling Assay (Affymetrix) according to vendor’s instructions. After fragmentation, cDNAs were hybridized for 17h at 45°C on Affymetrix Mouse Gene 1.0 ST Arrays. The Arrays were washed and stained in the GeneChip Fluidics Station 450 and scanned on a GeneChip Scanner 3000 7G (Affymetrix). Data intensities were log transformed and normalized with a quantile normalization method using Affymetrix Power Tools. Differentially expressed genes were identified according to statistical evidence indicated by Student's t-test and fold change statistics

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