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Depletion of MALAT1-dependent WTAP reduces aggressiveness of hypoxic TNBC cells

ABSTRACT: Numerous studies have identified long non-coding RNAs (lncRNA) as critical players in regulating tumor progression and metastasis formation. Here, we show that MALAT1 in hypoxic conditions, positively regulates WTAP protein expression, which influences the response to hypoxia by favoring the transcription of the master regulators HIF1A and HIF1B. Furthermore,WTAP stimulates BC cell migratory ability and the expression of N-Cadherin and Vimentin, hallmarks of epithelial-to-mesenchymal transition (EMT)

ORGANISM(S): Homo sapiens

PROVIDER: GSE240616 | GEO | 2024/06/20

REPOSITORIES: GEO

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Depletion of MALAT1-dependent WTAP reduces aggressiveness of hypoxic TNBC cells

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