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Serrate modulates N6-Methyladenosine (m6A) RNA modification in Arabidopsis

ABSTRACT: N6-methyladenosine (m6A) is the most common prevalent internal modifications found in many of the eukaryotic mRNA and plays an important role in RNA metabolism including pre-mRNA processing, mRNA stability, RNA splicing, RNA export and nuclear retention. Serrate is a component of the Dicer complex, plays as a key factor in RNA metabolism. We here reported SERRATE acts as a key regulator of mRNA m6A modification in Arabidopsis. Loss function of SE results in significant global m6A level reduction in the se-1 mutant comparing to the Col-0. SE positively regulates the transcription of MTA and MTB. In addition, SE physically interacts and functionally works with the m6A writer complex MTA and MTB which affects the binding of m6A methylase to mRNA. Taking together, our data provides a molecular framework that SE modulates m6A mRNA modification in Arabidopsis.

ORGANISM(S): Arabidopsis thaliana

PROVIDER: GSE241248 | GEO | 2023/11/01

REPOSITORIES: GEO

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Serrate modulates N6-Methyladenosine (m6A) RNA modification in Arabidopsis

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