Transcriptomics

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Rugulation of TNF-mediated macrophage differentiation and function by RBP-J


ABSTRACT: RBP-J was initially identified as a key regulator in the canonical Notch signaling pathway. More recent studies have unveiled its important role as a significant player in macrophage polarization, TLR and TNF signaling pathways. Since TNF activates RBP-J, we investigated the transcriptomic changes in murine bone marrow macrophages treated without or with TNF.

ORGANISM(S): Mus musculus

PROVIDER: GSE242269 | GEO | 2025/01/28

REPOSITORIES: GEO

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